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007			cr nn 008mamaa
008			140531s2014 xxua s 001 0 eng d
020			_a9781493907069
024	7		_a10.1007/978-1-4939-0706-9 _2doi
040			_aES-MaUEC
050		4	_aQH450 _b.M65 2014 EB
082	0	4	_a612
245	0	0	_aMolecular mechanisms and physiology of disease : _bImplications for Epigenetics and Health _cedited by Nilanjana Maulik, Tom Karagiannis
264		1	_aNew York _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XIV, 505 p.) _b43 ilustraciones, 33 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aEpigenetics in Childhood Health and Disease -- Role of Epigenetics in Neural Differentiation: Implications for Health and Disease -- An Overview of Epigenetic Mechanisms in Health and Disease -- Epigenetics: Role of Histone Proteases in Cellular Functions and Diseases -- Anti-inflammatory Effects of Probiotics and their Metabolites - Possible Role for Epigenetic Effects -- Epigenetics of Autoimmune Diseases -- The Effect of Nutrition and Exercise on Epigenetics and the Development of Cardiovascular Disease -- Epigenetic Events Associated with Obesity and Diabetes -- Molecular Mechanisms in the Development and Progression of Asthma: The Role of Epigenetic Regulation and the Airway Epithelium -- The Significance of Nanoparticles in Medicine and their Potential in Asthma -- One-carbon Metabolism Nutrients and Epigenetics: A Mechanistic Link Between Aberrant One-carbon Metabolism and Cancer Risk? -- Principles of the Warburg Effect and Cancer Metabolism -- Molecular Aspects of the Warburg Effect -- Epigenetic Perturbations in the Context of the Multi-hit Hypothesis of Carcinogenesis -- Epigenetic Mechanisms of Colon Cancer Prevention -- Dietary Antioxidants and Chromatin Modifying Compounds as Potential Anticancer Therapies -- Combination Therapy for Cancer - Phototherapy and HDAC Inhibition -- Nano-base Drug Delivery Modalities for the Treatment of Cancer: The Formulation of Tumour-specific and -targeted Nanoparticles.
520			_aIn a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_9162770 _aExpresión génica _0comprobar BNE20040069432 _2embne
650		7	_aFisiología humana _0comprobar BNE19900979803 _2embne _9140024
700	1		_aMaulik, Nilanjana _eeditor literario _985017 _0Local
700	1		_aKaragiannis, Tom _eeditor literario _985018 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-0706-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781493907069
907			_a.b12817466 _b28-10-17 _c01-10-14
998			_am _a_alco _a_vill _b15-09-17 _cm _dz _ei _feng _gxxu _h0
945			_aQH450 .M65 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11546682 _z06-04-17
999			_c76128 _d76128 _x1