000			03942nam a22003975i 4500
001			76115
003			ES-MaUEC
005			20230207040210.0
007			cr nn 008mamaa
008			140207s2014 xxu| s |||| 0|eng d
020			_a9781493904341
024	7		_a10.1007/978-1-4939-0434-1 _2doi
050		4	_aRA643.8 _b.B384 2014 EB
082	0	4	_a615.895
100	1		_aBauer, Gerhard _92056 _0comprobar BNE19911517419
245	1	0	_aGene therapy for HIV : _bfrom inception to a possible cure _cby Gerhard Bauer, Joseph S. Anderson
260			_aNew York _bSpringer International Publishing _c2014
300			_a1 recurso en línea (VIII, 72 p.) _b3 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aSpringerBriefs in Biochemistry and Molecular Biology _x2211-9353
505	0		_aPrinciples of Gene Therapy -- Injection of Naked DNA -- Non-Viral Gene Transfer (Transfection) Methods -- Viral gene transfer (transduction) methods -- Retroviruses -- Other viruses.-History of Gene Therapy.-Principles of HIV Gene Therapy.-Gene Therapy Vectors.-Lentiviral vectors.-Other modifications and additions.-Anti-HIV genes.-RNA-strategies.-Vector production.-Stem Cells for HIV Gene Therapy.-Pluripotent stem cells.-Animal Models Used in HIV Gene Therapy -- Murine models.-HIV infections in humanized mice.-Non-human primates.-Manufacturing of a GMP grade product for HIV gene therapy.-Clinical applications of HIV gene therapy.- Clinical trials of T cell gene therapy.-Stem cell gene therapy clinical trials for HIV.-Is A Cure for HIV Possible?
520			_aThis Brief describes the concept and realization of gene therapy for HIV from the unique historic perspective and insight of two pioneers of the clinical applications of stem cell gene therapy for HIV. Gerhard Bauer applied ribozyme-anti-HIV and other vectors to manufacture clinical grade, HIV-resistant hematopoietic stem cells for the first patients that received stem cell gene therapy for HIV, including the first child in the world and the first fully marrow-ablated HIV infected patient. Joseph Anderson developed the most recent and most potent combination anti-HIV lentiviral vectors and pluripotent stem cell applications for HIV gene therapy and tested these in the appropriate in vitro and vivo models, paving the way for novel HIV gene therapy approaches to possibly cure patients. In Gene Therapy for HIV, Bauer and Anderson discuss the unique aspects of this therapy, including its limitations and proper safety precautions and outline a path for a possible functional cure for HIV using stem cell gene therapy based on a cure already achieved with a bone marrow stem cell transplantation performed in Germany using donor stem cells with a naturally arising CCR5 mutation. In addition, the Brief provides a thorough and methodical explanation of the basics of gene therapy, gene therapy vector development, in vitro and in vivo models for HIV gene therapy and clinical applications of HIV gene therapy, including Good Manufacturing Practices
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aSIDA _0comprobar BNE19900988500 _2embne _9140699
650		7	_aInfecciones por VIH _0comprobar BNE19982759317 _2embne _9154434
650		7	_aEnfermedades inmunológicas _9142010 _0comprobar BNE19901007839 _2embne
700	1		_aAnderson, Joseph S. _984996 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4939-0434-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781493904341
907			_a.b12817338 _b27-10-17 _c01-10-14
998			_am _a_alco _a_vill _b27-10-17 _cm _dz _eb _feng _gxxu _h0
945			_aRA643.8 .B384 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11546554 _z06-04-17
999			_c76115 _d76115 _x1