000			03041nam a22003495i 4500
001			76106
003			ES-MaUEC
005			20230202101911.0
007			cr nn 008mamaa
008			140222s2014 xxu| s |||| 0|eng d
020			_a9781489980328
040			_aES-MaUEC
050		4	_aRC267 _b.S357 2014 EB
245	0	0	_aCancer Biology and the Nuclear Envelope : _bRecent Advances May Elucidate Past Paradoxes _cedited by Eric C. Schirmer, Jose I. de las Heras
260			_aNew York _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XIII, 611 p.) 98 il., 84 il. col.
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v773
520			_a"Nuclear envelope (NE) defects have been linked to cancer biology since the mid-1800s, but it was not until the last few years that we have begun to understand these historical links and to realize that there are myriad ways that the NE impacts on tumorigenesis. The NEÂ{u0A73} a complex double membrane system that encloses the genome while providing structural support through the intermediate filament lamin polymer and regulating protein/ mRNA trafficking and signaling between the nucleus and cytoplasm via the nuclear pore complexes (NPCs). These functions already provide some mechanisms for NE influences on cancer biology, but work in the past few years has elucidated many others. Lamins and many recently identified NE transmembrane proteins (NETs) have been now shown to function in DNA repair, regulation of cell cycle and signaling, apoptosis, cell migration in metastasis, and nuclear architecture and morphology. This volume presents a comprehensive overview of the wide range of functions recently identified for NE proteins and their relevance in cancer biology, providing molecular mechanisms and evidence of their value as prognostic and diagnostic markers, and suggesting new avenues for the treatment of cancer. Indeed some of these recent links are already yielding promising therapies, such as the current clinical trial of selective inhibitors of the nuclear export factor exportin in certain types of leukemia, melanoma and kidney cancer"
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aCáncer _xInvestigación _0comprobar BNE19901364217 _2embne _9182523
700	1		_aSchirmer, Eric C. _eeditor literario _984984 _0Local
700	1		_aHeras, Jose I. de las _eeditor literario _0Local _984985
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4899-8032-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781489980328
907			_a.b12817247 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b13-03-17 _cm _dz _ek _feng _gxxu _h0
945			_aRC267 .S357 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11546463 _z06-04-17
999			_c76106 _d76106 _x1