000			03094nam a22003495i 4500
001			76103
003			ES-MaUEC
005			20230207040209.0
007			cr nn 008mamaa
008			131121s2014 xxu| s |||| 0|eng d
020			_a9781489980021
040			_aES-MaUEC
050		4	_aRC628 _b.B769 2014 EB
100	1		_aBrown, Kristy A. _984977 _0Local
245	1	0	_aObesity and Breast Cancer : _bThe Role of Dysregulated Estrogen Metabolism _cby Kristy A. Brown, Evan R. Simpson
260			_aNew York _bSpringer International Publishing _c2014
300			_a1 recurso en línea (IX, 56 p.) 9 il., 7 il. col.
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aSpringerBriefs in Cancer Research
520			_aObesity is a risk factor for breast cancer in older women. A number of adipose-derived and obesity-related factors have been shown to affect tumour cell growth. These include adipokines, insulin, IGF-1 and oestrogens. The majority of obesity-related postmenopausal breast cancers are oestrogen-dependent. Since the ovaries no longer produce oestrogens after menopause, and that circulating levels are negligible, it is evident that it is the oestrogens produced locally within the breast adipose that are responsible for the increased growth of breast cancer cells. Aromatase is the enzyme that converts androgens into oestrogens and its regulation is dependent on the activity of a number of tissue-specific promoters.Â{u4872}geting oestrogen biosynthesis in obesity may be useful for the prevention of breast cancer.Â{u1CAF}omatase inhibitors are efficacious at treating postmenopausal breast cancer and recent studies suggest that they may also be useful in the prevention setting. However, these compounds inhibit the catalytic activity of aromatase and as a consequence lead to a number of undesirable side-effects, including arthralgia and possible cognitive defects due to inhibition of aromatase in the bone and brain, respectively. Novel therapies, such as those employed to treat obesity-associated disease, including anti-diabetics, may prove successful at inhibiting aromatase specifically within the breast.Â{u4A29}s SpringerBrief will explore all of these issues in depth and the authorsÂ{u1CA5} in a unique position to write about this topic,Â{u8876}ingÂ{u5E34}ensive experience in the field of aromatase research.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aObesidad _0comprobar BNE19900968586 _2embne _9139123
700	1		_aSimpson, Evan R. _984978 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4899-8002-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781489980021
907			_a.b12817211 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b10-03-17 _cm _dz _ea _feng _gxxu _h0
945			_aRC628 .B769 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11546438 _z06-04-17
999			_c76103 _d76103 _x1