000			04080nam a22003495i 4500
001			76101
003			ES-MaUEC
005			20230207040209.0
007			cr nn 008mamaa
008			140208s2014 xxu| s |||| 0|eng d
020			_a9781489973993
040			_aES-MaUEC
050		4	_aQH588.S83 _bE53 2014 EB
245	0	0	_aEndogenous Stem Cell-Based Brain Remodeling in Mammals _cedited by Marie-Pierre Junier, Steven G. Kernie
260			_aBoston, MA _bSpringer International Publishing _c2014
300			_a1 recurso en línea (VIII, 230 p.) 21 il., 19 il. col.
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aStem Cell Biology and Regenerative Medicine _x2196-8985
520			_aThis book uses the juvenile mammalian brain as a starting point to describe how different injury mechanisms influence neuronal and glial progenitor response to injury, and how in certain circumstances, these cells might play adaptive or harmful roles in recovery.Â{u0274} also provides an overview of emerging concepts in progenitor biology and how current understanding of the processes regulating these cells has tempered some of the initial enthusiasm regarding their therapeutic potential. Only recently has significant effort been devoted to the study of late neurogenesis in mammals, though this interesting phenomenon was first described over fifty years ago.Â{u026E} many settings, injury accelerates the ongoing neurogenesis now known to occur,Â{u1BA4} recently described reservoirs of glial progenitors add to the pool of existing reparative possibilities.Â{u0132}. Steven G. Kernie is an Associate Professor of Pediatrics and Pathology & Cell Biology at Columbia University in New York and Chief of Critical Care Medicine at Morgan Stanley Childrenâ€{u3808}ospital at Columbia University Medical Center. His laboratory is interested in how the brain repairs itself following injury. The presence of adult neural stem and progenitor cells in the mammalian brain has awakened new interest and optimism in potential treatment for a variety of acquired brain disorders. The Kernie lab is investigating how adult neural stem and progenitor cells participate in injury-induced remodeling and in identifying genes and drugs that might be important in augmenting their contribution. In order to do this, they have generated a variety of transgenic mice that allow for temporally controlled alterations in the endogenous stem cell population in order to optimize the post-injury remodeling that occurs. Dr. Marie-Pierre Junier is Research Director at Inserm and co-PI of team Glial Plasticity for the Center of Research Neuroscience Paris Seine at the University Pierre et Marie Curie. Her team showed the permissiveness of astrocytes to re-programming into immature states akin to neural progenitors or neural stem cells. It further demonstrated that these plastic capabilities of astrocytes sensitize them to cancerous transformation. The team is now using cancer stem cells isolated from human adult and pediatric gliomas to understand their differences from normal human neural stem cells. Combining proteomic, metabolic and epigenetic approaches, the team aims at developing new therapeutic strategies against these devastating cancers
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisando
650		7	_aCélulas madre _0comprobar BNE20022110396 _2embne _9160528
700	1		_aJunier, Marie-Pierre _eeditor literario _984973 _0Local
700	1		_aKernie, Steven G. _eeditor literario _0Local _984974
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4899-7399-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781489973993
907			_a.b12817193 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b13-03-17 _cm _dz _ek _feng _gxxu _h0
945			_aQH588.S83 E53 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11546414 _z06-04-17
999			_c76101 _d76101 _x1