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003			ES-MaUEC
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007			cr nn 008mamaa
008			140108s2014 xxu| s 000 0 eng d
020			_a9781461493174
024	7		_a10.1007/978-1-4614-9317-4 _2doi
040			_bES-MaUEC
050		4	_aRC685.M9 _bD53 2014 EB
082	0	4	_a572.6
245	0	0	_aDiabetic Cardiomyopathy : _bBiochemical and Molecular Mechanisms _cedited by Belma Turan, Naranjan S. Dhalla
260			_aNew York _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XIX, 416 p.) _b64 ilustraciones, 38 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Biochemistry in Health and Disease _v9
505	0		_aCardiac defects in diabetes -- Hormonal imbalance and neuropathy -- Role of oxidative stress -- Role of cation channel defects -- Abnormalities in glucose transport -- Fatty acid utilization -- Sarcolemmal Na+-K+ ATPase -- Sarcolemmal Ca2+-transport -- Sarcoplasmic reticular Ca2+-transport -- Intracellular Ca2+-homeostasis -- Mitochondrial function -- Contractile proteins -- β-adrenoceptor mechanisms -- Protein kinases and signal transduction -- Regulation of phopholipases -- Endothelin defects and cardiac dysfunction -- Metabolic changes in smooth muscles -- Metabolic defects in skeletal muscles -- Metabolic defects in brain -- Role of microangiopathy in heart dysfunction -- Role of nephropathy in heart dysfunction -- Prevention of diabetic-induced cardiac dysfunction -- Molecular targets for the therapy of diabetic cardiomyopathy
520			_aDiabetes has long been recognized as a disease of high blood sugar, and there has been a continuous search of the exact reason for its development and effective treatment. In 2005, the World Health Organization had estimated that more than 180 million people worldwide suffer from diabetes mellitus and indicated that this figure is likely to double within the next 20 years. Among the 3.8 million deaths each year associated with diabetes, about two thirds are attributable to cardiovascular complications, and diabetes is now considered to be a major metabolic risk factor for the occurrence of heart disease.Âĩabetic Cardiomyopathy: Biochemical and Molecular Mechanisms is a compilation of review articles devoted to the study on the topic with respect to biochemical and molecular mechanisms of hyperglycaemia. The wide range of areas covered here is of interest to basic research scientists, clinicians and graduate students, who are devoted to study the pathogenesis of diabetes-induced cardiovascular dysfunction. Furthermore, some chapters are directed towards increasing our understanding of novel ways for the prevention/treatment of cardiomyopathy. Twenty five articles in this book are organized in three sections. The first section discusses general aspects of the metabolic derangements in diabetic cardiomyopathy including metabolic alterations and substrate utilization as well as cardiac remodelling in the heart; role of diet in the development of metabolic syndrome in the heart; effect of hyperglycaemia in terms of biochemical and structural alterations in heart. In the second section, several cellular and molecular mechanisms are discussed indicating that diabetic cardiomyopathy is a multifactorial and complex problem. The third section discusses the prevention and treatment of diabetes using appropriate diet, proper supplements including antioxidants, angiotensin inhibitors and some other drugs. All in all, this book discusses the diverse mechanisms of diabetic cardiomyopathy with some information on new therapeutic approaches for finding solutions to prevent or reverse the development of cardiac dysfunction
650		7	_aMiocardio _xEnfermedades _9231884 _0comprobar BNE19960927334 _2embne
650	0	7	_aDiabetes _9138582 _2embne
700	1		_aTuran, Belma. _eeditor literario _984951 _0Local
700	1		_aDhalla, Naranjan S. _eeditor literario _0Local _984616
830		0	_aAdvances in Biochemistry in Health and Disease _v9 _9133167
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-9317-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12817065 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aRC685 .M9 D53 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11546281 _z06-04-17
988			_aEBOOK, EBSPRINGERrevisado
998			_am _a_alco _a_vill _b04-05-17 _cm _dz _eu _feng _gxxu _h0