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008			131113s2014 xxu| s |||| 0|eng d
020			_a9781461493020
024	7		_a10.1007/978-1-4614-9302-0 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQH671 _b2014 EB
245	0	0	_aCell Death : _bMechanism and Disease _cedited by Hao Wu.
264		1	_aNew York, NY _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XII, 272 páginas) _b46 ilustraciones, 42 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_a1. Historical Perspective â€{u0D28}e Seven Ages of Cell Death Research -- 2. The Intrinsic Apoptotic Pathway -- 3. Molecular Basis of Cell Death Programs in Mature T Cell Homeostasis -- 4. Bcl-2 family and their therapeutic potential -- 5. IAP proteins and their therapeutic potential -- 6. Cell Death and Cancer -- 7. The DNA damage response mediates apoptosis and tumor suppression -- 8. Neuronal Death Mechanisms in Development and Disease -- 9. The Complex Interplay Between Metabolism and Apoptosis -- 10. Programmed Necrosis/Necroptosis: An Inflammatory Form of Cell Death -- 11. Structural Perspectives on BCL-2 Family of Proteins -- 12. Structural basis of death receptor signaling.
520			_aBeginning from centuries of anecdotal descriptions of cell death, such as those on the development of the midwife toad in 1842 by Carl Vogt, to modern-day investigations of cell death as a biological discipline, it has become accepted that cell death in multicellular organisms is a normal part of life.Â{u4A29}s book provides a comprehensive view of cell death, from its mechanisms of initiation and execution, to its implication in human disease and therapy. Physiological cell death plays critical roles in almost all aspects of biology, and the book details its roles in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response.Â{u7A25}n physiological cell death goes awry, diseases can arise, and cancer is presented as a central paradigm for the consequences of derangements in the interplay between cell survival and cell death.Â{u1D20} the same time, the potential promise of targeted therapies aimed at interdicting cell death machineries are also discussed extensively.Â{u4A25} molecular mechanisms that underlie apoptotic cell death are illustrated from the perspectives of both the intrinsic, mitochondrial apoptotic pathway and the extrinsic, death receptor pathway.Â{uB979}y players in these pathways, such as the Bcl2 family proteins, cytochrome c, Apaf-1, caspases, death receptor adapter proteins, and inhibitor of apoptosis proteins, are presented from both functional and structural angles. Until only a few years ago, programmed cell death has been considered essentially synonymous with apoptosis.Â{u8BF7}wever, we now know that programmed cell death can also take other forms such as necrosis or necroptosis, and to this end, the mechanisms that underlie programmed necrosis in development and host defense are illustrated.Â{u4A25} past twenty plus years have seen an incredible growth of research in cell death, with one breakthrough after another, and the legacy still goes on with constant new surprises and findings.Â{uCBEE}ng live cell death! Hao Wu, Ph.D., is the Asa and Patricia Springer Professor at Harvard Medical School where she is a member of the Department of Biological Chemistry and Molecular Pharmacology. She is also a Senior Investigator in the Program in Cellular and Molecular Medicine at Boston Childrenâ€{u3808}ospital. Her research focuses on elucidating the molecular basis of signal transduction by immune receptors, including the induction of cell death pathways.
988			_aEBOOK, EBSPRINGERrevisado_2014
650		7	_aApoptosis _2embne _9157983
650		7	_aMuerte celular _2embne _9160237
700	1		_aWu, Hao _eeditor _984950
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-9302-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b10/2020 _dz _ek