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007			cr nn 008mamaa
008			131108s2014 xxu| s |||| 0|eng d
020			_a9781461491675
024	7		_a10.1007/978-1-4614-9167-5 _2doi
040			_aES-MaUEC
050		4	_aRB150.A67 _bH97 2014 EB
082	0	4	_a614.5999
245	0	0	_aHypoxia and cancer : _bbiological implications and therapeutic opportunities _cedited by Giovanni Melillo
260			_aNew York _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XIV, 363 páginas) _b53 ilustraciones, 36 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aCancer Drug Discovery and Development _x2196-9906
505	0		_aPreface -- Hypoxia and breast cancer metastasis -- Hypoxia and the DNA damage response -- Hypoxia and non-coding RNAs -- Hypoxia and ROS -- Hypoxia and gene expression -- Carbonic anhydrase IX: from biology to therapy -- Imaging the hypoxic tumor microenvironment in preclinical models -- Clinical imaging of hypoxia -- Hypoxia, antiangiogenic therapy and metastasis -- UPR and therapeutic opportunities -- Targeting the hypoxic phenotype -- Marianne Nordsmark: Hypoxia and Radiation therapy -- Pharmacological strategies targeting hypoxia -- Targeting the hypoxic tumor microenvironment -- Clinical exploitation of hypoxia -- Index
520			_aThe tremendous progress in our understanding of the molecular mechanisms underlying tumor hypoxias has generated a great deal of enthusiasm and provides new opportunities to better understand and target the tumor microenvironment. This book emphasizes how changes in oxygen levels in the tumor microenvironment impact cancer cell biology and provide new opportunities for cancer therapy and the contribution of world renowned experts in tumor hypoxia makes this text an invaluable tool for understanding how hypoxia impacts the biology, imaging and therapy of human cancers. Basic and translational scientists alike will find this book to be a source of updated information and an opportunity to further strategic thinking in order to better understand and target the complexity of the hypoxic tumor microenvironment. This book is a reference tool for students, scientists and clinicians who are interested in the role of hypoxia in cancer biology and therapy
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aAnoxemia _9157995 _0comprobar BNE20004397238 _2embne
650		7	_aAsfixia _9138265 _0comprobar BNE19900957708 _2embne
650		7	_aCáncer _xAspectos moleculares _9309464 _0comprobar BNE20011150872 _2embne
700	1		_aMelillo, Giovanni _eeditor literario _984946 _0Local
830		0	_aCancer Drug Discovery and Development _x2196-9906 _9133188
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-9167-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12817004 _b20-10-17 _c01-10-14
998			_am _a_alco _a_vill _b20-10-17 _cm _dz _eb _feng _gxxu _h0
945			_aRB150 .A67 H97 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11546220 _z06-04-17
999			_c76082 _d76082 _x1