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007			cr nn 008mamaa
008			131122s2014 xxu| s |||| 0|eng d
020			_a9781461490999
024	7		_a10.1007/978-1-4614-9099-9 _2doi
050		4	_aQP609.P78 _bR65 2014 EB
082	0	4	_a572.6
245	0	0	_aRole of Proteases in Cellular Dysfunction _cedited by Naranjan S. Dhalla, Sajal Chakraborti
260			_aNew York _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XI, 462 p.) _b58 ilustraciones, 46 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Biochemistry in Health and Disease _v8
505	0		_aPart A: Proteases and Neural Disorders.-Role of Calpain in Immunobiology of Neurodegenerative Diseases.-Calpain Interactions with the Protein Phosphatase Calcineurin in Neurodegeneration.-Involvement of Caspases in Neurodegenaration and Stroke.-Matrix Metalloproteinases in Ischemia-Reperfusion Injury in Brain: Antioxidants as Rescuer.-The Role of Matrix Metalloproteinases in Neurovascular Injury.-The Role of Proteases in Embryonic Neural Crest Cells.-Part B: Proteases and Cancer -- Proteases and Cancer Development.-Matrix Metalloproteinase and its Inhibitors in Cancer Progression.-Ubiquitin-Proteosome System in the Hallmarks of Cancer.-Matrix Metalloproteinases in Cancer Metastasis: An unsolved Mystery.-A Disintegrin and Metalloprotease-12 as a New target for Cancer Treatment -- Proteases and Their Role in Drug Development with an Emphasis in Cancer.-Part C: Proteases and Cardiovascular Defects.-Role of Matrix Metalloproteinases in Atherosclerosis.-The Importance of the Urokinase-type Plasminogen Activator (uPA) and its receptor (uPAR) for the Development and Progression of Atherosclerosis.-Matrix Metalloproteinases and Hypertension.-Regulation of Proteolysis in Vascular Remodeling.-Emerging Role of Genetic Variants of Matrix Metalloproteinases Genes in Left Ventricular Dysfunction.-Implications of Intracellular Proteolytic Activation of MMP-2 in the Heart.-Matrix Metalloprotease-2 in the Development and Progression of Cardiovascular Diseases.-Role of Protease Activation in Subcellular Remodeling and Heart Failure.-Proteases as Potential Targets in Left Ventricular Remodeling After Myocardial Infarction.-MMPs in Cardiovascular Diseases: Emerging Pharmacological Targets.-Proteases as Clinical Markers of Adverse Remodeling for Heart Failure in the Aging Population
520			_aIt is now well known that proteases are found everywhere, in viruses and bacteria as well as in all human, animal and plant cells, and play a role in a variety of biological functions ranging from digestion, fertilization, development to senescence and death. Under physiological conditions the ability of proteases is regulated by endogenous inhibitors. However, when the activity of proteases is not regulated appropriately, disease processes can result, as seen in Alzheimer's disease, cancer metastasis and tumor progression, inflammation and atherosclerosis. Thus it is evident that there is an absolute need for a tighter control of proteolytic activities in different cells and tissues. Aimed at graduate students and researchers with an interest in cellular proteolytic events, Role of Proteases in Cellular Dysfunctions is the second book on Proteases in this series. The book consists of three parts in specified topics based on current literatures for a better understanding for the readers with respect to their subject-wise interests. The first section of this book covers a brief idea about the neuronal disorders and the involvement of proteases such as calpains, caspases and matrix metalloproteases (MMPs). The second section covers the deadly disease cancer and its relation to ubiquitin-proteosomal system, MMPs and serine proteases. The last section is about the role of proteases such as calpains, MMPs and serine protease as well as urokinase type plasminogen activator receptor (uPAR) in causing cardiovascular defects
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aEnzimas proteolíticas _9146220 _0comprobar BNE19923137217 _2embne
700	1		_aDhalla, Naranjan S. _eeditor literario _0Local _984616
700	1		_aChakraborti, Sajal _eeditor literario _984935 _0Local
830		0	_aAdvances in Biochemistry in Health and Disease _v8 _9133167
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-9099-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461490999
907			_a.b12816942 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b31-07-17 _cm _dz _eb _feng _gxxu _h0
945			_aQP609 .P78 R65 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11546165 _z06-04-17
999			_c76076 _d76076 _x1