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008			140123s2013 xxu| s |||| 0|eng d
020			_a9781461490449
024	7		_a10.1007/978-1-4614-9044-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC720 _b2013 EB
245	0	4	_aThe Toxicant Induction of Irritant Asthma, Rhinitis, and Related Conditions _cedited by William J. Meggs.
264		1	_aBoston, MA _bSpringer International Publishing _c2013
300			_a1 recurso en línea (VI, 294 p.) _b24 ilustraciones, 18 ilustraciones en color
336			_aTexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aIntroduction: Irritant asthma, irritant rhinitis -- Airway Anatomy, Physiology, and Inflammation -- Reactive Airways Dysfunction Syndrome (RADS) and Irritant-Induced Asthma -- Acute Toxicity of Respiratory Irritant Exposures -- Particulate Exposure and Cardiovascular Inflammation -- Products of Combustion -- Irritant and Airborne Contact Dermatitis -- Exposure Limits -- Occupational Issues Related to Respiratory Irritants -- The Brain as a Target Organ for Allergic and Irritant Sensitivity: A Review and Suggestions for Research -- An Approach to Treating Irritant Airway Inflammation -- Summary and Research Needs -- Index.
520			_aUntoward reactions to environmental chemicals, particularly when a subject reports difficulties with exposures to chemicals of diverse classes involving more than one organ system, have been poorly understood and an area of great controversy. Studies of airway inflammation induced by respiratory irritants have established neurogenic inflammation as the mechanism for irritant asthma and rhinitis. Remodeling of the airway after an acute irritant exposure can lead to a heightened sensitivity to irritants that persists. Recognition that rhinitis, while sometimes regarded as a trivial disease, is associated with extra-airway manifestations such as fatigue and disturbances of sleep, mood, and cognition, further elucidates how chemical exposures can be serious for susceptible individuals. This book reviews current scientific understanding of irritant airway inflammation and related conditions, including cardiovascular effects of particulate exposures, airborne contact dermatitis and irritant dermatitis, and the brain as a target organ for both allergic and irritant reactions. It is essential reading for physicians and other healthcare workers caring for patients with environmental intolerances. Â{u1B2C}lergists, toxicologists, occupational and environmental physicians, and pulmonologists will find the materials particularly valuable. Patients and advocates for those with chemical intolerances will also find the book of interest.
988			_aEBOOK, EBSPRINGERrevisado_2013
650		7	_9676046 _aToxicología pulmonar _2embne
650		7	_aCiencias biomédicas _2embne _9143729
650		7	_aSalud pública _2embne _9138408
700	1		_aMeggs, William J. _eeditor _984931
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-9044-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b10/2020 _dz _eo