000			05210nam a22004335c 4500
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007			cr nn 008mamaa
008			131024s2014 xxu| s |||| 0|eng d
020			_a9781461489931
024	7		_a10.1007/978-1-4614-8993-1 _2doi
040			_aES-MaUEC
050		4	_aRS201.N35 _bN36 2014 EB
082	0	4	_a615
245	0	0	_aNanotoxicology : _bmaterials, methodologies, and assessments _cedited by Nelson Durán, Silvia S. Guterres, Oswaldo L. Alves
260			_aNew York _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XV, 411 p.) _b42 ilustraciones, 22 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aNanomedicine and Nanotoxicology _x2194-0452
505	0		_aForeword -- Preface -- Chapter 1: Nanomaterials -- Chapter 2: Concepts and Methodology of Interaction of Carbon Nanostructures with Cellular Systems -- Chapter 3: Nanostability -- Chapter 4: Pharmacokinetics and Phamacodynamics of Nanomaterials -- Chapter 5: In Vitro Cytotoxicity Assays of Nanoparticles on Different Cell Lines -- Chapter 6: Carbon Nanotubes: From Synthesis to Genotoxicity -- Chapter 7: From Combinatorial Display Techniques to Microarray Technology: New Approaches to the Development and Toxicological Profiling of Targeted Nanomedicines -- Chapter 8: Genetic Studies on the Effects of Nanomaterials -- Chapter 9: Cellular Mechanisms in Nanomaterial Internalization, Intracellular Trafficking and Toxicity -- Chapter 10: Cytotoxicity and Genotoxicity of Solid Lipid Nanoparticles -- Chapter 11: Cytotoxicity and Genotoxicity of Biogenically Synthesized Silver Nanoparticles -- Chapter 12: Cytotoxicity and Genotoxicity of Iron Oxides Nanoparticles -- Chapter 13: Poloxamers as Drug-Delivery Systems: Physico-Chemical, Pharmaceutical And Toxicological Aspects -- Chapter 14: Polymeric Nanoparticles: In Vivo Toxicological Evaluation, Cardiotoxicity and Hepatotoxicity -- Chapter 15: Cyto,Geno and Ecotoxicity of Copper Nanoparticles -- Chapter 16: Accessing the Erythrocyte Toxicity of Nanomaterials: From Current Methods to Biomolecular Surface Chemistry Interactions -- Index
520			_aThis book takes a systematic approach to nanotoxicology and the developing risk factors associated with nanosized particles during manufacture and use of nanotechnology. Beginning with a detailed introduction to engineered nanostructures, the first part of the book presents concepts and definitions of nanomaterials from quantum dots to graphene to fullerenes, with detailed discussion of functionalization, stability, and medical and biological applications. The second part critically examines methodologies used to assess cytotoxicity and genotoxicity. Coverage includes interactions with blood (erythrocytes), combinatorial and microarray techniques, cellular mechanisms, and ecotoxicology assessments. Part three describes cases studies both in vitro and in vivo for specific nanomaterials including solid lipid nanoparticles and nanostructured lipid carriers and metallic nanoparticles and metallic oxides. New information is also presented on toxicological aspects of poloxamers and polymeric nanoparticles as drug carriers as well as size effects on cytotoxicity and genotoxicity. Didactic aspects are emphasized in all chapters, making the book suitable for a broad audience ranging from advanced undergraduate and graduate students to researchers in academia and industry. In all, Nanotoxicology: Materials, Methodologies, and Assessments will provide comprehensive insight into biological and environmental interactions with nanostructures. Provides an introduction to nanostructures actually in use Describes cyto- and genotoxicity methodologies, and assesses their performance in comparison to common toxicity assays Discusses the relation of cytotoxicity and genotoxicity to ecotoxicity Presents a range of applications, from biogenic silver nanoparticles to poloxamers as drug-delivery systems, reflecting the expanding applications of nanotechnology
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aNanotecnología _0comprobar BNE20011268513 _2embne _9158453
650		7	_aTecnología farmacéutica _0comprobar BNE20030698632 _2embne _9161127
650		7	_aToxicología ambiental _0comprobar BNE20013502493 _2embne _9159275
700	1		_aDurán, Nelson _eeditor literario _984923 _0Local
700	1		_aGuterres, Silvia S. _eeditor literario _984924 _0Local
700	1		_aAlves, Oswaldo L. _eeditor literario _984925 _0Local
830		0	_aNanomedicine and Nanotoxicology _x2194-0452 _9133199 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-8993-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461489931
907			_a.b12816887 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b11-05-17 _cm _dz _eb _feng _gxxu _h0
945			_aRS201 .N35 N36 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11546104 _z06-04-17
999			_c76070 _d76070 _x1