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007			cr nn 008mamaa
008			131108s2014 xxu s 000 0 eng d
020			_a9781461486428
024	7		_a10.1007/978-1-4614-8642-8 _2doi
040			_beng
050		4	_aRC628 _b.G47 2014 EB
082	0	4	_a611.01816
082	0	4	_a599.935
245	0	4	_aThe Genetics of Obesity _cedited by Struan F.A. Grant
260			_aNew York _bSpringer International Publishing _c2014
300			_a1 recurso en línea (VIII, 128 p.) _b11 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aGenetic Variation and Obesity Prior to the Era of Genome-Wide Association Studies -- Genetic Obesity Syndromes -- Genome-Wide Association Studies of Obesity -- Copy Number Variants and their Contribution to the Risk of Obesity -- Genetics of Childhood Obesity -- Genetic Pleiotropies of Obesity -- Functional Follow-up of Genetic Variants Using FTO as the Prime Example -- Index
520			_aIn the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity, but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO), has been more robustly observed by others. Studies from both FTO knock out and FTO over expression mouse model support the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity. Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease. This book provides a comprehensive overview of efforts aimed at uncovering genetic variants associated with obesity, which have been particularly successful in the past 5 years with the advent of genome-wide association studies (GWAS). The Genetics of Obesity covers this state of the art technology and its application to obesity in great detail. Topics include genetics of childhood obesity, genetics of syndromic obesity, copy number variants and extreme obesity, co-morbidities of obesity genetics, and functional follow-up of genetic variants
650	0	7	_aObesidad _9139123 _2embne
650		7	_aEndocrinología _0comprobar BNE19900971669 _2embne _9139372
700	1		_aGrant, Struan F. A. _eeditor literario _0Local _984894
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-8642-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12816735 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aRC628 .G47 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11545951 _z06-04-17
988			_aEBOOK, EBSPRINGERrevisado
998			_am _a_alco _a_vill _b21-04-17 _cm _dz _eu _feng _gxxu _h4