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999			_c76042 _d76042
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003			ES-MaUEC
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007			cr nn 008mamaa
008			131002s2013 xxu| s |||| 0|eng d
020			_a9781461484127
024	7		_a10.1007/978-1-4614-8412-7 _2doi
040			_aES-MaUEC
050		4	_aRC71.3 _b.M65 2013 EB
082	0	4	_a614.5999
245	0	0	_aMolecular pathogenesis of colorectal cancer _cedited by Kevin M. Haigis
260			_aNew York _bSpringer International Publishing _c2013
300			_a1 recurso en línea (VIII, 316 p.) _b30 ilustraciones, 29 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPreface -- The Genetics of Colorectal Cancer -- Molecular Mechanisms of Colorectal Carcinogenesis -- The association between inflammation and colorectal cancer -- Importance of the niche: Wnt signalling and Stem cell plasticity in intestinal homeostasis and disease -- Mutational activation of KRAS and BRAF in colorectal cancer -- The PI3K pathway in Colorectal Cancers -- TGF- signaling pathway and colorectal cance -- The Clinical Significance of Mutations in Colorectal Cancer -- Colorectal Cancer Genome and Its Implications -- Copy-Number Alterations in the Colorectal Cancer Genome -- Genome-wide association studies in colorectal cancer -- Future prospects for leveraging molecular information in the fight against colorectal cancer -- Index
520			_aFor more than two decades, colorectal cancer has served as the paradigm for the cooperative activity of oncogenes and tumor suppressor genes in cancer initiation and progression. The depth of molecular characterization for this disease is unparalleled, with specific mutations correlated to each histologic stage of progression from normal colon to malignant colorectal cancer. We are now entering a time when molecular classification, rather than histologic classification, of cancer subtypes is driving the development of clinical trials with emerging targeted therapies. This book explores the past, present, and future of colorectal cancer genetics, with particular emphasis on how knowledge of the molecular pathogenesis of the disease leads to the development of novel therapeutic strategies. Individual chapters discuss general topics, such as genomic instability and inflammation, or else specific pathways, for example RAS, PI3K, and TGF-b, that play a role in colorectal cancer progression
650		7	_aDiagnóstico diferencial _0comprobar BNE19923778690 _2embne _9146590
650		7	_aColon _xCáncer _xDiagnóstico _9182269 _0comprobar BNE19901350829 _2embne
650		7	_aDiagnóstico molecular _0comprobar BNE20012504786 _2embne _9158916
700	1		_aHaigis, Kevin M. _eeditor literario _984873 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-8412-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461484127
907			_a.b12816607 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aRC71.3 .M65 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11545823 _z06-04-17
988			_aEBOOK, EBSPRINGERrevisado
998			_am _a_alco _a_vill _b08-05-17 _cm _dz _eb _feng _gxxu _h0