000			02688nam a22003375i 4500
001			76035
003			ES-MaUEC
005			20230207040206.0
007			cr nn 008mamaa
008			131203s2014 xxu| s |||| 0|eng d
020			_a9781461483175
040			_aES-MaUEC
050		4	_aQP601.3 _b.P76 2014 EB
245	0	0	_aProtein Deimination in Human Health and Disease _cedited by Anthony P. Nicholas, Sanjoy K. Bhattacharya
260			_aNew York _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XIII, 433 p.) 130 il., 75 il. col.
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
520			_aDeimination is a relatively new post-translational modification of proteins, whose recognition is ever-increasing. First linked to the pathology of rheumatoid arthritis (RA), deimination is a process by which selected positively charged arginine amino acids are converted to neutral citrulline amino acids by the peptidyl arginine deiminase (PAD) family of enzymes. Although the medical literature is rich with articles about the possible significance of deiminated proteins in RA, Protein Deimination in Human Health and Disease is the first publication to compile this knowledge and the growing amount of new information now known about the presence of deiminated proteins in the eye, skin, hair, gums, lung and nervous system, as well. As a result, this process has now been linked to numerous additional conditions besides RA, including cancer, glaucoma, Alzheimer's disease, Parkinson's disease, multiple sclerosis, spinal cord and peripheral nerve injury, Creutzfeldt-Jakob disease, among many others. Chronicling the earliest studies of deimination up to the present, this volume distills what is currently known about citrullination of proteins in the human body and is the first book of its kind on the topic. Â{u0823}
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aCinética química _0comprobar BNE20000304029 _2embne _9153087
700	1		_aNicholas, Anthony P. _eeditor _984857 _0Local
700	1		_aBhattacharya, Sanjoy K. _eeditor literario _0Local _984858
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-8317-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461483175
907			_a.b1281653x _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b22-03-17 _cm _dz _eu _feng _gxxu _h0
945			_aQP601.3 .P76 2014 EB _g0 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11617391 _z01-07-17
999			_c76035 _d76035 _x1