000			03000nam a22003735i 4500
001			76033
003			ES-MaUEC
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008			131008s2013 xxu| s |||| 0|eng d
020			_a9781461482895
040			_aES-MaUEC
050		4	_aQH431 _b.G33 2013 EB
245	0	0	_aGadd45 Stress Sensor Genes _cedited by Dan A. Liebermann, Barbara Hoffman
260			_aNew York _bSpringer International Publishing _c2013
300			_a1 recurso en línea (X, 134 p.) 18 il., 11 il. col.
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v793
520			_aEmerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress. The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins).These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity.Â{u01E1}dd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress. Â{u01B5}nctions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus.Âвotein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved. Â
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aGenética humana _0comprobar BNE19900986777 _2embne _9140562
650	0	7	_aEstrés (Fisiología) _0LocalV _2embne _9146565
700	1		_aLiebermann, Dan A. _eeditor _984854 _0Local
700	1		_aHoffman, Barbara _eeditor literario _934963 _0comprobar BNE20030736152
830		0	_aAdvances in Experimental Medicine and Biology _x0065-2598 _v793 _9133153
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-8289-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461482895
907			_a.b12816516 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b22-03-17 _cm _dz _eu _feng _gxxu _h0
945			_aQH431 .G33 2013 EB _g0 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11617378 _z01-07-17
999			_c76033 _d76033 _x1