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001			76013
003			ES-MaUEC
005			20230207040205.0
007			cr nn 008mamaa
008			130813s2013 xxu| s |||| 0|eng d
020			_a9781461479697
024	7		_a10.1007/978-1-4614-7969-7 _2doi
040			_aES-MaUEC
050		4	_aQP751 _b.S74 2013 EB
082	0	4	_a611.01816
082	0	4	_a599.935
245	0	0	_aStearoyl-CoA desaturase genes in lipid metabolism _cedited by James M. Ntambi
260			_aNew York _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XI, 239 p.) _b42 ilustraciones, 24 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aSCD genes of fatty acid synthesis -- SCD genes in heart metabolism -- SCD genes in liver metabolism -- SCD genes in harderian and perpetual glands -- SCD genes In lipogenesis -- SCD genes lipoproteins -- SCD genes in WAT -- SCD genes in muscle -- SCD genes in the brain -- SCD genes in inflammation -- SCD genes in ER Stress -- SCD genes in skin -- SCD genes in insulin signaling -- SCD genes in thermogenesis -- SCD genes in diabetes -- SCD genes atherosclerosis -- SCD genes in Adipocyte differentiation -- SCD genes and epigenetics -- SCD genes in fatty liver disease -- SCD genes in Colitis -- SCD genes in leptin signaling
520			_aJames Ntambi has gathered top authors to write about the remarkable growth of research on the role of the stearoyl-CoA desaturase (SCD) genes in metabolism in different species including human. The book shows that beginning with simple cellular models of differentiation a broad and comprehensive analysis of the SCD gene family in a number of species and biological systems has been carried out over the course of the last twenty five years. SCD is a central enzyme in lipid metabolism that synthesizes monounsaturated fatty acids (MUFA) from saturated fatty acid precursors. At first glance, SCD would be considered a housekeeping enzyme because its product oleate is a well-known MUFA that is abundant in many dietary sources and tissue lipids. A particular highlight in the chapters of the book is that MUFAs may have signaling properties that regulate metabolism. For example, a proper ratio of saturated to MUFA contributes to membrane fluidity, and oleate has also been implicated as a mediator of signal transduction, cellular differentiation and metabolic homeostasis. It is also highlighted that SCD-1 repression mediates the metabolic effects of the hormone leptin. Conditional alleles and corresponding tissue-specific knockout mouse models for many of the SCD gene isorfms have provided a wealth of information on not only tissue-specific fatty acid metabolism but also the key transcription factors that regulate SCD expression under a variety of metabolic and genetic backgrounds. The studies described indicate that control of SCD expression occurs via a series of complex signal transduction schemes making SCD one of the most highly studied lipogenic gene families to date
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aLípidos _0comprobar BNE19901029068 _2embne _9142933
650		7	_aLípidos _xMetabolismo _9179199 _0comprobar BNE19901285095 _2embne
700	1		_aNtambi, Ph.D., James M. _eeditor literario _984815 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-7969-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461479697
907			_a.b12816310 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b08-05-17 _cm _dz _eb _feng _gxxu _h0
945			_aQP751 .S74 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11545690 _z06-04-17
999			_c76013 _d76013 _x1