000			04242nam a22003735i 4500
001			76009
003			ES-MaUEC
005			20230207040205.0
007			cr nn 008mamaa
008			130808s2014 xxu| s |||| 0|eng d
020			_a9781461479314
024	7		_a10.1007/978-1-4614-7931-4 _2doi
050		4	_aQH599 _b.S97 2014 EB
082	0	4	_a614.5999
245	0	0	_aSystems Analysis of Chromatin-Related Protein Complexes in Cancer _cedited by Andrew Emili, Jack Greenblatt, Shoshana Wodak
260			_aNew York _bSpringer International Publishing _c2014
300			_a1 recurso en línea (XI, 316 p.) _b52 ilustraciones, 50 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aPreface -- Systematic proteomic analysis of histone demethylating enzymes linked to cancer -- Histone methylating protein complexes in cancer -- Chromatin protein-protein interaction networks linked to cancer -- Structural genomics and drug discovery for chromatin-related protein complexes involved in histone tail recognition -- Transcription factories and global chromatin (enhancer) interactions in cancer -- Long ncRNAs associated with chromatin complexes and their role in cancer -- Familial and somatic mutations of histone modifying enzymes in cancer -- Chromatin regulators arising from RNAi screens of transformed cancer cell lines -- Chromatin complexes in cancer -- Exploring dynamics of chromatin complexes in cancer based on quantitative proteomics -- Regulatory ncRNAs and their targets -- ncRNA regulatory networks in cancer -- Decoding BAF remodelling complexes in cancer -- Mediator/cohesin complex in cancer -- miRNAs targeting chromatin-related protein complexes regulate epigenetic states in cancer -- Polycomb group protein complexes in cancer stem cells -- Genetic interactions between chromatin factors in cancer cell lines -- Chromatin complexes in DNA repair -- Chromatin complexes in chromosome segregation -- Evolution, co-expression and domain architecture of CM complexes linked to cancer -- Index
520			_aEpigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research. Chromatin structure and function are modified by protein complexes, causing genes to be turned "on" or "off" and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized. To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines - namely, the "readers, writers and erasers" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery. What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aCáncer _xAspectos genéticos _9273952 _0comprobar BNE19990911214 _2embne
650		7	_aCromatina _0comprobar BNE19912513685 _2embne _9144121
700	1		_aEmili, Andrew _eeditor literario _0Local _984804
700	1		_aGreenblatt, Jack _eeditor literario _984805 _0Local
700	1		_aWodak, Shoshana _eeditor literario _984806 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-7931-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
907			_a.b12816279 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b04-04-17 _cm _dz _eu _feng _gxxu _h0
945			_aQH599 .S97 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11545653 _z06-04-17
999			_c76009 _d76009 _x1