000			03182nam a22003855i 4500
001			76005
003			ES-MaUEC
005			20230207040205.0
007			cr nn 008mamaa
008			130829s2013 xxu| s |||| 0|eng d
020			_a9781461478553
024	7		_a10.1007/978-1-4614-7855-3 _2doi
040			_aES-MaUEC
050		4	_aQP609.P56 _bP76 2013 EB
082	0	4	_a572.6
245	0	0	_aProtein Tyrosine Phosphatase control of metabolism _cedited by Kendra K. Bence
260			_aNew York _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XI, 273 p.) _b34 ilustraciones, 24 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aRedox Regulation of PTPs in Metabolism: Focus on Assays -- Quantitative Modeling of PTPs and Implications for Studying Metabolic Signaling -- Protein-Tyrosine Phosphatase 1B Substrates and Control of Metabolism -- PTP1B and TCPTP in CNS Signaling and Energy Balance -- PTP1B in the Periphery: Regulating Insulin Sensitivity and ER Stress -- Role of Protein Tyrosine Phosphatase 1B in Hepatocyte-Specific Insulin and Growth Factor Signaling -- PTP1B in Obesity-Related Cardiovascular Runction -- Role of SHP2 Protein Tyrosine Phosphatase in Cardiac Metabolism -- Metabolic Effects of Neural and Pancreatic SHP2 -- Protein Tyrosine Phosphatase Epsilon as a Regulator of Body Weight and Glucose Metabolism -- The Role of LMPTP in the Metabolic Syndrome -- Mitogen-Activated Protein Kinase Phosphatases in Metabolism -- Glycogen Metabolism and Lafora Disease -- Index
520			_aTyrosine phosphorylation is a rapid and reversible protein modification catalyzed by the yin and yang activities of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). A multitude of PTPs have been implicated in human disease, with a growing number of PTPs now known to play major roles in prevalent metabolic diseases including obesity and type 2 diabetes. Recent studies into PTP function in the context of metabolism highlight the importance of understanding the specific substrates and binding partners of these enzymes, the regulation of PTP activity, and the cell/tissue specificity of PTP functions. This volume contains chapters which highlight many aspects of PTP function in the context of metabolism
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650	0	4	_aProteína cinasas _9510854
650		7	_aBioquímica _0comprobar BNE19900962333 _2embne _9138639
650		7	_aEndocrinología _0comprobar BNE19900971669 _2embne _9139372
700	1		_aBence, Kendra K. _eeditor literario _984798 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-7855-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461478553
907			_a.b12816231 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b08-05-17 _cm _dz _eb _feng _gxxu _h0
945			_aQP609 .P56 P76 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11545616 _z06-04-17
999			_c76005 _d76005 _x1