000			02782nam a22003255i 4500
001			75993
003			ES-MaUEC
005			20230202101835.0
007			cr nn 008mamaa
008			130716s2013 xxu| s |||| 0|eng d
020			_a9781461476603
040			_aES-MaUEC
050		4	_aRC268.48 _b.A35 2013 EB
245	0	0	_aAdipose Tissue and Cancer _cedited by Mikhail G. Kolonin
260			_aNew York _bSpringer International Publishing _c2013
300			_a1 recurso en línea (VIII, 190 p.)
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
520			_aThe pathophysiology underlying the relationship between obesity and cancer is complex and incompletely understood. Progression of certain cancers has been shown to accelerate in obese patients irrespective of their lifestyle and diet. Because obesity is manifested by overgrowth of white adipose tissue, it has been proposed that adipose tissue has a direct effect on cancer progression. Adipose tissue is composed of several types of cells secreting numerous soluble factors collectively termed adipokines. In addition, infiltration of the immune system cells in obesity leads to increased production of a number of inflammatory factors by adipose tissue, thus contributing to the establishment of the metabolic syndrome. Endocrine signaling by adipose tissue-derived molecules has been shown to promote cancer in animal models, matching clinical associations. Recent studies have shown that cells from adipose tissue are capable of trafficking to tumors, thus enabling paracrine action of adipokines from within the tumor microenvironment. Increased tumor vascularization, immune system suppression and direct effects on malignant cell survival and proliferation have been investigated as mechanisms regulated by adipokines. This volume will discuss clinical and experimental data pointing to the role of adipose tissue in cancer and to dissect individual mechanisms through which adipose tissue excess or restriction could influence cancer progression.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aCáncer _xEtiología _9170296 _0comprobar BNE19901092798 _2embne
700	1		_aKolonin, Mikhail G. _eeditor literario _984781 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-7660-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461476603
907			_a.b12816115 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b10-03-17 _cm _dz _ef _feng _gxxu _h0
945			_aRC268.48 .A35 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11545495 _z06-04-17
999			_c75993 _d75993 _x1