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001			75983
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008			130614s2013 xxu| s |||| 0|eng d
020			_a9781461473183
040			_aES-MaUEC
050		4	_aRC662.4 _bF376 2013 EB
100	1		_aFarooqui, Akhlaq A. _984762 _0Local
245	1	0	_aMetabolic Syndrome : _bAn Important Risk Factor for Stroke, Alzheimer Disease, and Depression _cby Akhlaq A. Farooqui
260			_aNew York _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XX, 412 p.) 86 il., 46 il. col.
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
520			_aThe metabolic syndrome is a cluster of common pathologies: abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension. At the molecular level, metabolic syndrome is accompanied not only by dysregulation in the expression of adipokines, cytokines, and chemokines but also by alterations in insulin and leptin signaling, oxidative stress, and chronic low grade inflammation. These changes affect immune responses and mediate chronic inflammation leading to alterations in the hypothalamic â€b̃odyweight/appetite/satiety set pointâ€{uE809}t is becoming increasingly evident that metabolic syndrome is a risk factor for neurological disorders such as stroke, depression, and Alzheimer disease (AD). Family history, age, environmental and lifestyle factors (diet and physical inactivity, and exposure to toxins) are closely associated with predisposition for the development of metabolic syndrome as well as neurological disorders. The incidences of stroke are 2 to 4-fold higher in patients with metabolic syndrome and cardiovascular diseases compared to normal subjects of the same age. Similarly, patients with metabolic syndrome have a 2 to 3-fold increased risk for developing dementia and AD. Metabolic syndrome doubles the risk of depression. The molecular mechanism underlying the mirror relationship between metabolic syndrome and neurological disorders is not fully understood. However, biochemical alterations observed in metabolic syndrome like induction of chronic inflammation and oxidative stress, impairment of endothelial cell function, induction of insulin and leptin resistance, hyperglycemia-related increase in advanced glycation end-products, and micro-vascular injury may represent a pathological bridge between metabolic syndrome and neurological disorders. It is hoped that Metabolic Syndrome: An important risk factor for stroke, Alzheimer disease, and depression will be useful to postgraduate students, faculty, research scientists, pharmacologists, nutritionists, and physicians, who are curious about the molecular mechanisms that link metabolic syndrome with stroke, Alzheimer disease, and depression.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aResistencia a la insulina _9160785 _0comprobar BNE20022641968 _2embne
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-7318-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461473183
907			_a.b12816012 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b26-02-17 _cm _dz _eo _feng _gxxu _h0
945			_aRC662.4 F376 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11545392 _z06-04-17
999			_c75983 _d75983 _x1