000			03142nam a22004095i 4500
999			_c75966 _d75966 _x1
001			75966
003			ES-MaUEC
005			20230214040152.0
007			cr nn 008mamaa
008			130402s2013 xxu| s |||| 0|eng d
020			_a9781461468868
024	7		_a10.1007/978-1-4614-6886-8 _2doi
040			_aES-MaUEC
050		4	_aQR400.2.E68 _bF73 2013 EB
082	0	4	_a614.5999
100	1		_aFrappier, Lori _984726 _0Local
245	1	0	_aEBNA1 and Epstein-Barr virus associated tumours _cby Lori Frappier
260			_aNew York _bSpringer International Publishing _c2013
300			_a1 recurso en línea (VII, 43 p.) _b5 ilustraciones, 4 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aSpringerBriefs in Cancer Research _v3
505	0		_aIntroduction -- Roles of EBNA1 at EBV Episomes -- EBNA1-DNA Interactions -- EBNA1 Contributions to EBV-associated Tumours -- Cellular Effects of EBNA1 -- Conclusion
520			_aThis SpringerBrief is comprehensive account of the functions and effects of the Epstein-Barr virus (EBV) EBNA1 protein that relate to EBV-associated cancers and evidence for EBNA1 contributions to these cancers. ℗¡ EBNA1 was the first EBV protein detected and the most critical for EBV latent infection. EBNA1 fulfills multiple functions at EBV genomes which have been described in many (sometimes confusing) reports over the last 28 years. While these were initially thought to be the only roles of EBNA1, many reports in recent years have shown that EBNA1 also directly affects cellular processes in ways that would be expected to contribute to oncogenesis. However, the degree to which EBNA1 promotes cell survival and oncogenesis in various types of human tumours is not entirely clear and a matter of debate. This℗¡book offers℗¡a current℗¡synopsis of EBNA1 functions in EBV latency, including functions in DNA replication, mitotic segregation and transcription. Mechanisms of these EBNA1 functions is also discussed as well as implications for tumourigenesis. In addition, the cellular effects of EBNA1 will be reviewed, including how EBNA1 manipulates specific cellular proteins and relationships to EBV-associated lymphomas and carcinomas
650	0	7	_aEnfermedades víricas _9413118 _2embne
650		7	_aVirus del herpes _0comprobar BNE19923470105 _2embne _9146295
650		7	_aEnfermedades víricas _0comprobar BNE19901004195 _2embne _9413118
650		7	_aCáncer _xInvestigación _0comprobar BNE19901364217 _2embne _9182523
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-6886-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461468868
907			_a.b12815846 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQR400.2 .E68 F73 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11545227 _z06-04-17
988			_aEBOOK, EBSPRINGERrevisado
998			_am _a_alco _a_vill _b04-05-17 _cm _dz _eb _feng _gxxu _h0