000			02425nam a22003375i 4500
001			75957
003			ES-MaUEC
005			20230202101822.0
007			cr nn 008mamaa
008			130403s2013 xxu| s |||| 0|eng d
020			_a9781461465287
040			_aES-MaUEC
050		4	_aRC267 _b.V47 2013 EB
245	0	0	_aVesicle trafficking in cancer _cedited by Yosef Yarden, Gabi Tarcic
260			_aNew York _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XIV, 393 p.) _b50 il., 47 il. col.
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
520			_aEndocytosis and vesicular trafficking determine the landscape of the cellâ€{u3825}xterior, namely the density of surface molecules, such as receptors for growth factors and cytokines, adhesion molecules like integrins and cadherins, and a plethora of nutrient carriers. Hence, endocytosis is involved in signal transduction, cell adhesion and migration, as well as metabolism. To exploit these fundamental processes, malignancies subtly and multiply manipulate the endocytosis and the subsequent trafficking of protein cargoes. This is achieved by simultaneously altering the cytoskeleton, vesicle budding, cargo sorting and intracellular degradation. By highlighting the underlying molecular processes and concentrating on specific examples, this book reviews the recent emergence of derailed endocytosis and vesicular trafficking as a landmark of cancer. In-depth understanding of this common feature of tumors might lead the way to drug-induced strategies, able to rectify intracellular trafficking in cancer
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aCáncer _xInvestigación _0comprobar BNE19901364217 _2embne _9182523
700	1		_aYarden, Yosef _eeditor literario _984709 _0Local
700	1		_aTarcic, Gabi _eeditor literario _984710 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-6528-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461465287
907			_a.b12815755 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b23-03-17 _cm _dz _eb _feng _gxxu _h0
945			_aRC267 .V47 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11545136 _z06-04-17
999			_c75957 _d75957 _x1