000			02979nam a22003495i 4500
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001			75953
003			ES-MaUEC
005			20230202101821.0
007			cr nn 008mamaa
008			130507s2013 xxu| s |||| 0|eng d
020			_a9781461464648
040			_aES-MaUEC
050		4	_aRC374.C48 _bP43 2013 EB
245	0	0	_aPharmacoresistance in Epilepsy : _bfrom genes and molecules to promising therapies _cedited by Luisa Rocha, Esper A. Cavalheiro
260			_aNew York _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XII, 329 p.) _b40 il., 26 il. col
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
520			_aAlthough more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one-third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy, and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoresistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they{u2019}re studying epilepsy in the lab or treating it in a doctor{u2019}s office
650		7	_aEpilepsia _xTratamiento _9189452 _0comprobar BNE19920890636 _2embne
650		7	_aQuimioterapia _9138367 _2embne
700	1		_aRocha, Luisa _eeditor literario _984701 _0Local
700	1		_aCavalheiro, Esper A. _eeditor literario _984702 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-6464-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461464648
907			_a.b12815718 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aRC374.C48 P43 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11545094 _z06-04-17
988			_aEBOOK, EBSPRINGERrevisado
998			_am _a_alco _a_vill _b23-03-17 _cm _dz _eb _feng _gxxu _h0