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007			cr nn 008mamaa
008			121117s2013 xxu| s |||| 0|eng d
020			_a9781461458944
024	7		_a10.1007/978-1-4614-5894-4 _2doi
040			_aES-MaUEC
050		4	_aQP552.G59 _bP76 2013 EB
082	0	4	_a614.5999
245	0	0	_aProminin-1 (CD133) : _bnew insights on stem & cancer stem cell biology _cedited by Denis Corbeil
260			_aNew York _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XV, 250 p.) _b29 ilustraciones, 28 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v777
505	0		_aPreface -- Prominin-1 (CD133): Molecular and Cellular Features Across Species -- Prominin-2 and Other Relatives of CD133 -- Prominin-1-containing Membrane Vesicles: Origins, Formation and Utility.- Prominent Role of Prominin in the Retina -- Gene Regulation of Prominin-1 (CD133) in Normal and Cancerous Tissues -- Prominin-1 (CD133) and the Cell Biology of Neural Progenitors and Their Progeny -- CD133-Positive Hematopoietic Stem Cells: From Biology to Medicine -- New Insights into the Renal Progenitor Cells and Kidney Diseases by Studying CD133 -- CD133 Expression Strongly Correlates with the Phenotype of Very Small Embryonic/Epiblast-like Stem Cells -- New Insights into the CD133 (Prominin-1) Expression in Mouse and Human Colon Cancer Cells -- Prominin-1 (CD133) Expression in the Prostate and Prostate Cancer: A Marker for Quiescent Stem Cells -- Prominin-1 (CD133) Reveals New Faces of Pancreatic Progenitor Cells and Cancer Stem Cells: Current Knowledge and Therapeutic Perspectives -- Prominin-1 (CD133) and Metastatic Melanoma: Current Knowledge and Therapeutic Perspectives -- CD133-Positive Cells for Cardiac Stem Cell Therapy: Current Status and Outlook -- CD133+ Cells for the Treatment of Degenerative Diseases: Update and Perspectives -- Index
520			_aProminin-1 or otherwise known as CD133 is a glycoprotein that is present in humans and mice. Since the first description of prominin in 1997, in mouse neuroepithelial cells and in human hematopoietic stem cells as AC133 antigen, this molecule has aroused a large interest especially, as a stem cell marker, that gave rise to an ever growing body of publications and more recently its expression in cancer stem cells. Controversies as to its role as a cancer stem and its detection in different models, as well as its use as a prognostic marker have emerged. Yet, beyond its use as a stem cell and cancer stem cell marker, prominin-1/CD133 displays unique biological features and appears of importance in other processes like for example in retinal biogenesis. Indeed, this five-transmembrane plasma membrane glycoprotein, which marks membrane protrusions is associated with several essential processes like cell polarity, asymmetric cell division and membrane remodeling. We propose to review current knowledge about this intriguing molecule and present pertinent information to determine the biological role of prominins and assess their importance in medicine and cancer research. The primary audience for this book is geared towards scientists and researchers with interest in cancer stem cells, stem cells, cell biology, neurobiology, and regenerative medicine
650	0	7	_aGlucoproteínas _9670257 _2embne
650		7	_aOncología _0comprobar BNE19900969554 _2embne _9139207
650	0	7	_aCáncer _xInvestigación _0LocalV _2embne _9182523
700	1		_aCorbeil, Denis _eeditor literario _984653 _0Local
830		0	_aAdvances in Experimental Medicine and Biology _x0065-2598 _v777 _9133153
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-5894-4 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461458944
907			_a.b12815445 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP552 .G59 P76 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i1154482x _z06-04-17
988			_aEBOOK, EBSPRINGERrevisado
998			_am _a_alco _a_vill _b04-05-17 _cm _dz _eb _feng _gxxu _h0