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| 003 | ES-MaUEC | ||
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| 008 | 121026s2013 xxu| s |||| 0|eng d | ||
| 020 | _a9781461454809 | ||
| 040 | _aES-MaUEC | ||
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_aQH588.S83 _bI46 2013 EB |
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| 245 | 0 | 4 |
_aThe Immunological Barriers to Regenerative Medicine _cedited by Paul J. Fairchild |
| 260 |
_aNew York, NY _bSpringer International Publishing _c2013 |
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| 300 | _a1 recurso en línea (XIII, 334 p.) 34 il., 26 il. col. | ||
| 336 |
_aTexto (visual) _btxt _2rdacontent |
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| 337 |
_aelectrónico _bc _2rdamedia |
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| 338 |
_arecurso electrónico _bcr _2rdacarrier |
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| 490 | 1 | _aStem Cell Biology and Regenerative Medicine | |
| 520 | _aRecent years have witnessed numerous advances in stem cell research that have suggested novel strategies for the treatment of the chronic and regenerative diseases that pose a growing challenge to the provision of healthcare in the 21st century.ÂYvertheless, there is little doubt that related disciplines have failed to keep pace with such developments, of which the immunology of transplant rejection is perhaps the most relevant to the nascent field of regenerative medicine.Â{u026E}deed, given that after decades of research into the mechanisms of organ allograft rejection, we remain wholly dependent on immune suppression to ensure acceptance of foreign tissues, we might legitimately ask whether there is any reason why tissues differentiated from stem cells might not suffer the same fate.This volume seeks to address this issue by drawing on the principles of alloantigen recognition to assess the validity of early convictions that embryonic stem cell-derived tissues may prove invisible to the immune system of the host and the more recent belief that induced pluripotent stem cells, derived in a fully autologous manner, will circumvent the issue of immunogenicity.Â{u0221}ving debunked such assumptions and established the magnitude of the immunological barriers to be overcome, this book then draws on the expertise of internationally-recognised laboratories around the world to provide a critical assessment of the likely success of applying strategies such as stem cell banking, silencing of genes that confer immunogenicity, and the induction of transplantation tolerance to overcoming the immunological barriers in the future.Â{u026E}deed, it is only through reaching a consensus in the field that enduring solutions to such an intractable problem may ultimately emerge | ||
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| 988 | _aEBOOK, EBSPRINGERrevisado | ||
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_aCélulas madre _0comprobar BNE20022110396 _2embne _9160528 |
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| 700 | 1 |
_aFairchild, Paul J. _eeditor _984628 _0Local |
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| 830 | 0 |
_aStem Cell Biology and Regenerative Medicine _9133169 _0Local |
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_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-5480-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid) |
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