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008			121116s2013 xxua s 0|1 0 eng d
020			_a9781461453383
024	7		_a10.1007/978-1-4614-5338-3 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC360 _b.P68 2013 EB
245	0	0	_aPrions and Diseases _nVolume 2, _pAnimals, Humans and the Environment _cedited by Wen-Quan Zou, Pierluigi Gambetti
264		1	_aNew York _bSpringer International Publishing _c2013
300			_a1 recurso en línea (IX, 295 p.) _b31 ilustraciones, 20 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aBovine Spongiform Encephalopathy -- Classical and Atypical Scrapie in Sheep and Goats -- Sporadic Human Prion Disease -- Environmentally-acquired Transmissible Spongiform -- Prions in the Environment -- The Spectrum of Tau Pathology in Human Prion Disease -- Risk of Transmission of Creutzfeldt-Jakob Disease by Blood Transfusion -- Species Barriers in Prion Disease -- Transgenic Mice Modelling -- Prion Transmission Studies in Transgenic Mice -- Alternative Models of Prion Diseases -- Diagnosis of Prion Disease: Conventional Approaches -- Quaking-induced Conversion (QuIC) Assays for the Detection and Diagnosis of Prion Diseases -- Overview on Treatment of Prion Diseases and Decontamination of Prions -- Immunomodulation.
520			_aTransmissible spongiform encephalopathies (TSE), now broadly known as prion diseases, have been recognized for nearly 300 years in animals and almost 100 years in humans. However, the nature of the transmissible agent had largely remained a mystery until Stanley Prusiner discovered the infectious isoform of the prion protein (PrP), named prion or scrapie PrP (PrPSc), in 1982. The subsequent modern studies with protein chemistry and molecular biology in cell culture, transgenic animals, and cell-free systems, including the revolutionary protein-misfolding cyclic amplification (PMCA), have greatly advanced our understanding of the pathogenesis of prion diseases and facilitated the identification of new prion diseases in animals and humans. In Prions and Prion Diseases, more than 60 leading researchers and clinicians worldwide provide an up-to-date development in many aspects of these unique infectious pathogens and their associated diseases. Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aSistema nervioso central _xEnfermedades _0comprobar BNE19913498802 _2embne _9188115
650		7	_aNeurociencias _0comprobar BNE20012490612 _2embne _9158907
650		7	_aNeurología _0comprobar BNE19900967585 _2embne _9139040
700	1		_aZou, Wen-Quan _eeditor literario _984619 _0Local
700	1		_aGambetti, Pierluigi _eeditor literario _984620 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-5338-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461453383
907			_a.b12815214 _b28-10-17 _c01-10-14
942			_2lcc _cLE
945			_aRC360 .P68 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11544594 _z06-04-17
998			_dz _ei _feng _gxxu _h0