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008			121207s2013 xxu| s |||| 0|eng d
020			_a9781461451075
040			_aES-MaUEC
050		4	_aQP623 _b.T46 2013 EB
100	1		_aChan, Edward K. L. _eeditor literario _984613 _0Local
245	0	0	_aTen Years of Progress in GW/P Body Research _cedited by Edward K. L. Chan, Marvin J. Fritzler
260			_aNew York _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XI, 276 p.) _b47 ilustraciones, 25 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v768
505	0		_aPreface -- The GW body Story as an Example of Autoantibodies with Significant Impacts to Molecular Cell Biology -- The Discovery of GW Bodies -- The Discovery and Analysis of P Bodies -- Autoantibodies to Argonaute 2 (Su antigen) -- GW/P Bodies and Autoimmune Disease -- Function of GW182 and GW Bodies in siRNA and miRNA Pathways -- Post-Transcriptional Stimulation of Gene Expression by MicroRNAs -- Gawky (Gw) is the Drosophila Melanogaster GW182 Homologue -- The Role of GW182 Proteins in miRNA-mediated Gene Silencing -- Quantifying Argonaute Proteins in and out of GW/P-bodies: Implications in microRNA Activities -- Deadenylation and P-bodies -- Relationship of GW/P-bodies with Stress Granules -- Relationship of other Cytoplasmic Ribonucleoprotein (RNP) Bodies to GW/P Bodies -- A SNP in the Trinucleotide Repeat Region of the TNRC6A Gene Maps to a Major TNGW1 Autoepitope in Patients with Autoantibodies to GW182 -- Reflections on Ten Years of History of, and Future Prospects for, GW182 and GW/P Body Research -- Index.
520			_aGW bodies are novel cytoplasmic foci that were discovered and named by Dr. Chanâ€{u3827}roup in 2002.Â{u4A25}se bodies are now known to be active cytoplasmic foci involved with the new gene regulation process mediated by microRNA that leads to translational repression and mRNA degradation.Â{u4A25} detailed biological functions of these cytoplasmic structures are still being uncovered and the idea for this book is to provide the history of the discovery and the major work from different laboratories that has led to the characterization and elucidation of the structure and function of these new multiple subcellular structures.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aARN _0comprobar BNE19913480892 _2embne _9144940
700	1		_aFritzler, Marvin J. _eeditor literario _0Local _984614
830		0	_aAdvances in Experimental Medicine and Biology _x0065-2598 _v768 _9133153
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-5107-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461451075
907			_a.b12815147 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b17-03-17 _cm _dz _ea _feng _gxxu _h0
945			_aQP623 .T46 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11544521 _z06-04-17
999			_c75896 _d75896 _x1