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008			121117s2013 xxu| s |||| 0|eng d
020			_a9781461450375
040			_aES-MaUEC
050		4	_aQP616.D54 _bD53 2013 EB
245	0	0	_aDNA Helicases and DNA Motor Proteins _cedited by Maria Spies
260			_aNew York _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XII, 299 p.) _b69 ilustraciones, 58 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v973
505	0		_aPreface -- Overview: What are DNA helicases? -- Structure and mechanisms of SF1 DNA helicases -- Structure and mechanisms of SF2 DNA helicases -- Structure and mechanisms of hexameric helicases -- Helicases at the replication fork -- DNA helicases associated with genetic instability, cancer and aging -- The Helicase-primase complex as a target for effective herpesvirus antivirals -- RecQ helicases - conserved guardians of genetic integrity -- Roles of DNA helicases in the mediation and rRegulation of homologous recombination -- DNA helicases in NER, BER andÂ?R -- Roles for helicases as ATP-dependent molecular switches -- The FtsK family of DNA pumps -- ATP dependent chromatin remodelers -- Index.
520			_aIn recent years, a number of groundbreaking structural and mechanistic studies deepened our understanding of helicase mechanisms and established new approaches for their analyses. Many fundamental mechanistic questions ranging from the mechanism of force generation, mechanochemical coupling to distinct mechanisms by which the same enzyme translocates on DNA removing obstacles, unwinds DNA and/or remodels nucleoprotein complexes, however, remain to be answered. It is even less understood how the helicase motors are incorporated into a wide range of genome maintenance and repair machines. The field has reached a stage when the studies of molecular mechanisms and basic biology of helicases can and shall be integrated with the studies of development, cancer and longevity. The objective of this book is to provide the first systematic overview of structure, function and regulation of DNA helicases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studiesÂ{u4A25} editorsÂ{u1A6D} to provide a unified view on how helicases function in the cell, are regulated in response to different cellular stresses and are integrated into large macromolecular assemblies to form a complex and adaptive living system.
650		7	_aADN _0comprobar BNE19900989837 _2embne _9140806
700	1		_aSpies, Maria _eeditor literario _984609 _0Local
830		0	_aAdvances in Experimental Medicine and Biology _x0065-2598 _v973 _9133153
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-5037-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461450375
907			_a.b12815111 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP616.D54 D53 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11544491 _z06-04-17
988			_aEBOOK, EBSPRINGERrevisado
998			_am _a_alco _a_vill _b17-03-17 _cm _dz _ea _feng _gxxu _h0