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001			75887
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008			121206s2013 xxu| s |||| 0|eng d
020			_a9781461449546
040			_aES-MaUEC
050		4	_aQP623 _b.B56 2013 EB
245	0	0	_aBiophysics of RNA Folding _cedited by Rick Russell
260			_aNew York _bSpringer International Publishing _c2013
300			_a1 recurso en línea (VI, 236 p.) _b71 ilustraciones, 55 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aBiophysics for the Life Sciences _v3
505	0		_aIntroduction -- Comparative Analysis of the Higher-order Structure of RNA -- Graph Applications to RNA Structure and Function -- Prediction and Coarse-Grained Modeling of RNA Structures -- RNA Folding Using Site-Directed Spin Labeling -- The RNA Recognition Motif and Messenger RNA -- Memory Effects in RNA folding dynamics revealed by single molecule fluorescence -- An integrated picture of HDV ribozyme catalysis -- Combining biochemical and structural information to model RNA-protein complex assembly -- Following RNA Folding From Local and Global Perspectives -- The Roles of Chaperones in RNA Folding.
520			_aStructured RNAs are everywhere, functioning throughout gene expression with key roles ranging from catalysis to regulation. New functional RNAs are being discovered all the time; in fact, it is now clear that a much greater fraction of eukaryotic genomes is devoted to coding for RNA than protein. Many of these RNAs must traverse complex energy landscapes to find their functional three-dimensional structures. Along the way, they may encounter native and non-native folding intermediates, chaperone proteins, and assemble with partner proteins. This volume, written by experts in the field, discusses the current understanding of the biophysical principles that govern RNA folding, with featured RNAs including the ribosomal RNAs, viral RNAs, and self-splicing introns. In addition to the fundamental features of RNA folding, the central experimental and computational approaches in the field are presented with an emphasis on their individual strengths and limitations, and how they can be combined to be more powerful than any method alone; these approaches include NMR, single molecule fluorescence, site-directed spin labeling, structure mapping, comparative sequence analysis, graph theory, course-grained 3D modeling, and more. This volume will be of interest to professional researchers and advanced students entering the field of RNA folding.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aARN _0comprobar BNE19913480892 _2embne _9144940
700	1		_aRussell, Rick _eeditor literario _984595 _0Local
830		0	_aBiophysics for the Life Sciences _v3 _9133159
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-4954-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461449546
907			_a.b12815056 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b17-03-17 _cm _dz _ea _feng _gxxu _h0
945			_aQP623 .B56 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11544430 _z06-04-17
999			_c75887 _d75887 _x1