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001			75883
003			ES-MaUEC
005			20230207040201.0
007			cr nn 008mamaa
008			120913s2013 xxu| s |||| 0|eng d
020			_a9781461448150
024	7		_a10.1007/978-1-4614-4815-0 _2doi
040			_aES-MaUEC
050		4	_aRM301.25 _b.M53 2013 EB
082	0	4	_a615.19
245	0	0	_aMicrodialysis in drug development _cedited by Markus Müller
260			_aNew York _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XI, 338 p.) _b55 ilustraciones, 29 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAAPS Advances in the Pharmaceutical Sciences Series _x2210-7371 _v4
505	0		_aIntroduction to the Microdialysis Technology -- Recovery and Calibration Techniques: Toward Quantitative Microdialysis -- Analytical Considerations for Microdialysis Sampling -- Regulatory Aspects of Microdialysis: A United States Food & Drug Administration Perspective -- Microdialysis in CNS PKPD Research: Unraveling Unbound Concentrations -- Microdialysis in Antibiotic Research -- Skin and Transdermal Drug Delivery: Advantages and Challenges -- Translational Approaches For Predicting CNS Drug Effects Using Microdialysis -- Extracellular Amyloid-β Protein Dynamics in Alzheimer's Disease -- Microdialysis in Pain Research -- Microdialysis in Ocular Drug Development -- Microdialysis in Metabolic Research -- High Molecular Weight Targets and Treatments Using Microdialysis -- Complementary Techniques Positron Emission Tomography -- Open Flow Microperfusion: An Alternative Method to Microdialysis? -- Microdialysis in Internal Organs and Tumors.
520			_aIn vivo target site concentrations are probably th most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970ies, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650	0	7	_aFarmacología _xInvestigación _0LocalV _2embne _9183058
650		7	_aIndustria farmacéutica _0comprobar BNE19900958956 _2embne _9138366
700	1		_aMüllerr, Markus _eeditor literario _984590 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-4815-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461448150
907			_a.b12815019 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b29-03-17 _cm _dz _eb _feng _gxxu _h0
945			_aRM301.25 .M53 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11544399 _z06-04-17
999			_c75883 _d75883 _x1