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020			_a9781461447566
040			_aES-MaUEC
050		4	_aQP535.N2 _bS63 2013 EB
245	0	0	_aSodium Calcium Exchange : _bA Growing Spectrum of Pathophysiological Implications : Proceedings of the 6th International Conference on Sodium Calcium Exchange _cedited by Lucio Annunziato
260			_aBoston, MA _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XXV, 463 p.) _b133 ilustraciones, 53 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v961
505	0		_aPart I. Historical Perspective -- 1. Livin with NCX and Lovin It: 45 Year Romance -- 2. 20 Years from NCX Purification and Cloning: Milestones -- Part II Structural and Functional Aspects of NCX -- 3. Ca2+ Regulation in the Na+/Ca2+ Exchanger Features a Dual Electrostatic Switch Mechanism -- 4. Molecular Determinants of Allosteric Regulation in NCX Proteins -- 5. NCX1: Mechanism of Transport -- 6. Structural Studies of the Ca2+ Regulatory Domain of Drosophila Na+/Ca2+ Exchanger CALX -- 7. Interplay of Ca2+ and Mg2+ in Sodium-Calcium and in other Ca2+ Binding Proteins. Magnesium: Watchdog That Blocks Each Turn If Able -- Part III. Structural and Functional Aspects of NCKX -- 8. Functional and Structural Properties of the NCKX2 Na+-Ca2+/K+ Exchanger: a Comparison with the NCX1 Na+/Ca2+ Exchanger -- 9. NCKX5, a Natural Regulator of Human Skin Colour Variation Regulates the Expression of Key Pigment Genes mc1r and alpha-MSH, and Alters Cholesterol Homeostasis in Normal Human Melanocytes -- 10. Expression and Regulation of Sodium/Calcium Exchangers, NCX and NCKX, in Reproductive Tissues: Do They Play a Critical Role in Calcium Transport for Reproduction and Development? -- Part IV. Genetic and Epigenetic Regulation -- 11. Transcriptional Pathways and Potential Therapeutic Targets in the Regulation of NCX1 Expression in Cardiac Hypertrophy and Failure -- 12. Transcriptional Regulation of ncx1 Gene in the Brain -- Part V. Regulatory Mechanisms of NCX -- 13. Metabolic Regulation of the Squid Nerve Na+/Ca2+ Exchanger: Recent Developments -- 14. Regulation of Sodium-Calcium Exchanger Activity by Creatine Kinase -- 15. Coordinated Regulation of Cardiac Na<+/Ca2+ Exchanger and Na+-K+-ATPase by Phospholemman (FXYD1) -- Part VI. Subcellular Localization and Function of NCX in Ca2+-Storing Organelles and Mitochondria -- 16. Mitochondria Na+-Ca2+ Exchange in Cardiomyocytes and Lymphocytes -- 17. New Insights in Mitochondrial Calcium Handling by Sodium/Calcium Exchanger -- Part VII. NCX in Neurodegenerative Diseases -- 18. Genetically-Modified Mice as a Strategy to Unravel the Role Played by the Na+/Ca2+ Exchanger in Brain Ischemia and in Spatial Learning and Memory Deficits -- 19. NCX as a Key Player in the Neuroprotection Exerted by Ischemic Preconditioning and Postconditioning -- 20. The Role of the Mitochondrial NCX in the Mechanism of Neurodegeneration in Parkinson�isease -- 21. The Contribution of the Sodium-Calcium Exchanger (NCX) and Plasma Membrane Ca2+-ATPase (PMCA) to Cerebellar Synapse Function -- Part VIII. Emerging Role of NCX Activity in Immune and Glial Cells -- 22. Sodium-Calcium Exchanger Modulates the L-Glutamate Ca2+-signalling in Type-1 Cerebellar Astrocytes -- 23. Immunosupressive Drugs, Immunophilins and Functional Expression of NCX Isoforms -- 24. Calcium Influx Through Reversed ncx Controls Migration Of Microglia -- 25. Sodium Fluxes and Astroglial Function -- 26. New Roles of NCX in Glial Cells: Activation Of Microglia in Ischemia and Differentiation of Oligodendrocytes -- 27. Human Macrophages and Monocytes Express Functional Na+/Ca2+ Exchangers 1 and 3 -- Part IX. NCX in the Hearth and Vascular Smooth Muscle -- 28. New Insights into the Contribution of Arterial NCX to the Regulation of Myogenic Tone and Blood Pressure -- 29. Toward an Understanding of the Complete NCX1 Lifetime in the Cardiac Sarcolemma -- Part X. NCX Role in Hypertension, Heart Failure, Ischemia-Reperfusion, Arrhythmias, and Diabetes -- 30. Cardiac Sodium-Calcium Exchange and Efficient Excitation-Contraction Coupling: Implications for Heart Disease -- 31. Cross-talk Between Plasma Membrane Na+/Ca2+ Exchanger-1 and TRPC/ORAI Containing Channels: Key Players in Arterial Hypertension -- 32. T-tubule Remodeling and Ryanodine Receptor Organization Modulate Sodium-Calcium Exchange -- 33. Na+/ Ca2+ Exchange and the Plasma Membrane Ca2+-ATPase in β-Cell Function and Diabetes -- Part XI. NCX Partners in Ionic Homeostasis: ASIC, NMDA, NHE, and TRPC -- 34. The Na+/H+ Exchanger NHE5 is Sorted to Discrete Intracellular Vesicles in the Central and Peripheral Nervous Systems -- 35. The Role of Na+/H+ Exchanger Isoform 1 in Inflammatory Responses: Maintaining H+ Homeostasis of Immune Cells -- 36. Acid-sensing Ion Channels in Pathological Conditions -- 37. Non-Selective Cation Channels and Links to Hippocampal Ischemia, Aging and Dementia.
520			_aThis book reports the text of the lectures of the 6th International Conference on Sodium Calcium Exchange held in Lacco Ameno in the Island of Ischia in the Gulf of Naples, Italy, from October 1 to October 5, 2011.The present book uncovers the most striking new findings on NCX that emerged since the previous Conference on Sodium Calcium Exchange, such as the structural dissection of the molecular determinants of Ca2+ sensitivity of the exchanger, the epigenetic regulation of ncx1 gene, the molecular identification of the mitochondrial Sodium Calcium Exchanger, and the discovery of NCX in unexpected anatomical locations such as the female reproductive tract.The book is organized into 11 parts covering NCX structural aspects, genetic and epigenetic regulation, regulatory mechanisms, subcellular localization in mitochondria, involvement in neurodegenerative diseases and in immune regulation, and the role of the cardiovascular and endocrine systems, as well as diabetes in physiology and pathophysiology. Selected chapters of the book are also devoted to the interaction of NCKX and other ion channels and transporters with NCX, like ASICs, TRPM, and NHE
650	0	7	_aElementos químicos _9138656 _0LocalV _2embne
700	1		_aAnnunziato, Lucio _eeditor literario _984586 _0Local
830		0	_aAdvances in Experimental Medicine and Biology _x0065-2598 _v961 _9133153
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-4756-6 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461447566
907			_a.b12814994 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP535.N2 S63 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11544375 _z06-04-17
988			_aEBOOK, EBSPRINGERrevisado
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