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008			121026s2013 xxu| s |||| 0|eng d
020			_a9781461447443
040			_aES-MaUEC
050		4	_aQP623.5.S63 _bR53 2013 EB
245	0	0	_aRNA Interference from Biology to Therapeutics _cedited by Kenneth A. Howard
260			_aBoston, MA _bSpringer International Publishing _c2013
300			_a1 recurso en línea (XV, 337 p.) _b46 ilustraciones, 35 ilustraciones en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Delivery Science and Technology _x2192-6204
505	0		_aRNA Interference Pathways and Therapeutic Exploitation RNA Interference -- Synthetic Dicer-Substrate siRNAs as Triggers of RNA Interference -- The Role of MicroRNAs in Natural Tissue Development and Application in Regenerative Medicine -- Intracellular Delivery Considerations for RNAi Therapeutics -- Mucosal Delivery of RNAi Therapeutics -- Nanomedicines for Systemic Delivery of RNAi Therapeutics -- Lipidoids: A Combinatorial Approach to siRNA Delivery -- Polymeric Micelles for siRNA Delivery -- RNAi Therapeutic Delivery by Exosomes -- Aptamer-Mediated siRNA Targeting -- RNAi as Anti-Viral Therapy: The HIV-1 Case -- Genome-Wide RNAi Screen for Identification of Human Host Factors Crucial for Influenza Virus Replication -- The Application of microRNAs in Cancer Diagnostics -- Therapeutic Application of miRNAs in Cancer -- Clinical Development of an Inhalable Anti-RSV siRNA Treatment.
520			_aThe Nobel Prize winning discovery that small interfering RNA can be utilised to control cellular gene expression has propelled the field of RNA interference (RNAi) to the forefront of biomedical science as a potential molecular medicine set to revolutionalise disease treatment.Â{u2820} Harnessing the molecular mechanisms of RNAi and development of delivery technologies is crucial for its transformation into a therapeutic modality, this dependency is the focus of “RNA Interference from Biology to Therapeuticsâ€{u0D28}at gives a comprehensive overview of RNAi biology and state-of-the-art delivery methods relevant to clinical translation of RNAi therapeutics. Key players and shapers in the fields of RNAi and delivery science have been assembled in a single volume to produce a truly unique interdisciplinary text, making it a “must-readâ€{u09AF}r both students and experts in, and at the interface of, RNAi, pharmaceutical science and medicine. An attractive feature is the “future perspectivesâ€{u0CE5}ction within each chapter that allows global leaders the opportunity to express their views on the direction the field is moving. Topics covered in the book include miRNA biology and therapeutic exploitation, exosome delivery and clinical translation. “RNA Interference from Biology to Therapeuticsâ€{u0A73} an up-to-the-minute, highly informative and invaluable text for those actively involved or interested in this fascinating and high-impact field.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aARN _0comprobar BNE19913480892 _2embne _9144940
650		7	_9140525 _aÁcidos nucleicos _0comprobar BNE19900986351 _2embne
700	1		_aHoward, Kenneth A. _eeditor literario _984582 _0Local
830		0	_aAdvances in Delivery Science and Technology _x2192-6204 _9133164
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-4744-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461447443
907			_a.b12814970 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b17-03-17 _cm _dz _ea _feng _gxxu _h0
945			_aQP623.5.S63 R53 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11544351 _z06-04-17
999			_c75879 _d75879 _x1