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| 008 | 130228s2013 xxu| s |||| 0|eng d | ||
| 020 | _a9781461443162 | ||
| 040 | _aES-MaUEC | ||
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_aRM301.28 _b.B56 2013 EB |
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| 245 | 0 | 0 |
_aBiophysics for therapeutic protein development _cedited by Linda O. Narhi |
| 260 |
_aNew York _bSpringer International Publishing _c2013 |
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| 300 |
_a1 recurso en línea (IX, 293 p.) _b108 il. col |
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| 336 |
_aTexto (visual) _btxt _2rdacontent |
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| 337 |
_aelectrónico _bc _2rdamedia |
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| 338 |
_arecurso electrónico _bcr _2rdacarrier |
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| 490 | 1 |
_aBiophysics for the Life Sciences _v4 |
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| 520 | _aThe last few decades have seen the genesis of protein therapeutics, such that these large molecule based drugs comprise an increasingly larger part of the commercial market. The conformation (overall global fold or three-dimensional structure) of these molecules is important for maintaining biological activity, stability during long term storage, and can impact the safety profile and biological consequences of administration. For this reason at every stage of product discovery and development biophysical methods play a key analytical role in product development, as they are applied for the determination of protein higher order structure. In addition to helping define binding kinetics and other parameters important for target validation, they are the only techniques available to determine if a potential protein product is folded properly, and can maintain this active conformation during manufacturing, storage, and delivery. Thus the biophysical techniques play a key role during the development of protein therapeutics. This volume is organized to mimic the product lifecycle. The initial chapters describe the underlying theory, and strengths and weaknesses of the different techniques commonly used during therapeutic development. The majority of the chapters discuss the applications of these techniques, including case studies, across the product lifecycle from early discovery, where the focus is on identifying targets, and screening for potential drug product candidates, through expression and purification, large scale production, formulation development, lot-to-lot comparability studies, and commercial support including investigations. There is also a chapter from the perspective of the regulatory agencies. This book can be used to provide insight into this important application of biophysics for those who are planning a career in protein therapeutic development, and for those outside this area who are interested in understanding it better | ||
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_2lcc _cLE |
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| 988 | _aEBOOK, EBSPRINGERrevisado | ||
| 650 | 7 |
_aFarmacología _0comprobar BNE19900953030 _2embne _9137893 |
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| 650 | 7 |
_aBiofísica _0comprobar BNE19900968115 _2embne _9139082 |
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| 650 | 7 |
_aProteínas _0comprobar BNE19900977845 _2embne _9139861 |
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| 700 | 1 |
_aNarhi, Linda O. _eeditor literario _984552 _0Local |
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_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-4316-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid) |
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