000			03328nam a22003735i 4500
001			75857
003			ES-MaUEC
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008			120919s2013 xxu| s |||| 0|eng d
020			_a9781461441182
040			_aES-MaUEC
050		4	_aRM301.63 _b.C66 2013 EB
245	0	0	_aComplement therapeutics _cedited by John D. Lambris, V. Michael Holers, Daniel Ricklin
260			_aBoston _bSpringer International Publishing _c2013
300			_a1 recurso en línea (VIII, 320 p.) _b151 il. col.
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	1		_aAdvances in Experimental Medicine and Biology _x0065-2598 _v735
520			_aThis book highlights progress and trends in the rapidly evolving field of complement-related drug discovery and spotlights examples of clinical applications. As an integral part of innate immunity and critical mediator in homeostatic and inflammatory processes, the human complement system has been identified as contributor to a large number of disorders including ocular, cardiovascular, metabolic, autoimmune, and inflammatory diseases as well as in ischemia/reperfusion injury, cancer and sepsis. In addition, complement is often involved in adverse immune reactions to biomaterials, cell and organ transplants or drug delivery systems. Although the complement cascade with its close to 50 extracellular protein targets has long been recognized as an attractive system for therapeutic modulation, the past few years have seen a particularly strong boost in interest. Fueled by novel research insight and the marketing of the first complement-targeted drugs, a plethora of highly creative treatment approaches and potent drug candidates have recently emerged and are currently evaluated in disease models and clinical trials. The chapters in this book cover a wide range of topics related to the development of complement therapeutics, ranging from the molecular and functional description of complement targets to the presentation of novel inhibitors, improved treatment strategies as well as examples of disease models and clinical applications. The broad and up-to-date overview on a highly versatile and dynamic field renders this book an indispensable source of information for researchers and clinicians dealing with therapeutic and disease-related aspects of the human complement system
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aDrogas _0comprobar BNE19900969879 _2embne _9139235
650		7	_aTerapeútica _9138037 _0comprobar BNE19900954749 _2embne
700	1		_aLambris, John D. _eeditor literario _0Local _984215
700	1		_aHolers, V. Michael _eeditor literario _984542 _0Local
700	1		_aRicklin, Daniel _eeditor literario _984543 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-4118-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461441182
907			_a.b12814751 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b14-03-17 _cm _dz _eb _feng _gxxu _h0
945			_aRM301.63 .C66 2013 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11544132 _z06-04-17
999			_c75857 _d75857 _x1