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008			140324s2014 xxua s |01 0 eng d
020			_a9781461432098
040			_aES-MaUEC
050		4	_aRE661.D3 _bR485 2014 EB
082	0	4	_a617.7
245	0	0	_aRetinal Degenerative Diseases : _bMechanisms and Experimental Therapy _cedited by John D Ash, Christian Grimm, Joe G Hollyfield, Robert E Anderson, Matthew M LaVail, Catherine Bowes Rickman
260			_aNew York _bSpringer International Publishing _c2014
300			_a1 recurso en línea (LXI, 862 p.) 188 il., 187 il. en color
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aAdvances in Experimental Medicine and Biology, _v801
520			_aThis book will contain the proceedings of the XV International Symposium on Retinal Degeneration (RD2012). A majority of those who will speak and present posters at the meeting will contribute to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the 'best' and 'most important' meetings in the field. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy. While advances in these areas of retinal degenerations will be described, there will be many new topics that either were in their infancy or did not exist at the time of the last RD Symposium, RD2010. These include the role of inflammation and immunity, as well as other basic mechanisms, in age-related macular degeneration, several new aspects of gene therapy, and revolutionary new imaging and functional testing that will have a huge impact on the diagnosis and following the course of retinal degenerations, as well as to provide new quantitative endpoints for clinical trials. The retina is an approachable part of the central nervous system (CNS), and there is a major interest in neuroprotective and gene therapy for CNS diseases and neurodegenerations, in general. It should be noted that with successful and exciting initial clinical trials in neuroprotective and gene therapy, including the restoration of sight in blind children, the retinal degeneration therapies are leading the way towards new therapeutic measures for neurodegenerations of the CNS. Many of the successes recently reported in these areas of retinal degeneration sprang from collaborations established at previous RD Symposia, and many of those will be reported at the RD2010 meeting and included in the proposed volume. We anticipate the excitement of those working in the field and those afflicted with retinal degenerations will be reflected in the volume.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aRetina _xEnfermedades _9190667 _0comprobar BNE19921008313 _2embne
700	1		_aAsh, John _eeditor literario _0Local _910139
700	1		_aGrimm, Christian _eeditor literario _98523 _0comprobar BNE19920001539
700	1		_aHollyfield, Joe G. _eeditor literario _0Local _984492
700	1		_aAnderson, Robert E. _eeditor literario _0Local _984493
700	1		_aLaVail, Matthew M. _eeditor literario _0Local _984494
700	1		_aBowes Rickman, Catherine _eeditor literario _984495 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-1-4614-3209-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781461432098
907			_a.b12814507 _b13-10-17 _c01-10-14
998			_am _a_alco _a_vill _b26-02-17 _cm _dz _ei _feng _gxxu _h0
945			_aRE661.D3 R485 2014 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11543887 _z06-04-17
999			_c75832 _d75832 _x1