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001			75729
003			ES-MaUEC
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007			cr nn 008mamaa
008			100301s2006 ne | s |||| 0|eng d
020			_a9781402039980
040			_aES-MaUEC
050		4	_aRD663 _b.S354 2006 EB
082	0	4	_a614.5999
100	1		_aSchiffer, Davide _984284 _0Local
245	1	0	_aBrain Tumor Pathology : _bCurrent Diagnostic Hotspots and Pitfalls _cby Davide Schiffer
260			_aDordrecht _bSpringer International Publishing _c2006
300			_a1 recurso en línea (VI, 272 p.)
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
338			_aonline resource _bcr _2rdacarrier
520			_aSince Bailey and Cushing (1926), all brain tumor classifications have been called histogenetic. The nosographic position that the tumor types progressively acquired in the classification systems derived from the resemblance of tumor cells to those of the cytogenesis, modified whenever new information became available from different biological research fields and especially from molecular genetics. Classically, on the basis of the rough correspondence between the mature/immature aspect of tumor cells and the benign/malignant biological behavior of the tumors, the histological labels contained a prognostic significance. The supposed origin of the tumors was thus a factor for prognosis. Later on, with the concept of anaplasia (Cox, 1933; Kernohan et al., 1949) new criteria were introduced for establishing the malignancy grades of tumors. Immunohistochemistry and later molecular genetics further refined the prognostic diagnoses, substantially increasing the opportunities to recognize the cell origin of tumors, beside revealing the pathogenetic mechanisms. Prognoses became more accurate, as required by the greater and more targeted possibilities of therapy.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aCerebro _xTumores _9214753 _0comprobar BNE19932355375 _2embne
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/1-4020-3998-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9781402039980
907			_a.b12813473 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b03-01-17 _cm _dz _ef _feng _gne _h0
945			_aRD663 .S354 2006 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11542858 _z06-04-17
999			_c75729 _d75729 _x1