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008			100609s2006 xxu| s |||| 0|eng d
020			_a9780387472577
040			_aES-MaUEC
050		4	_aQP623 _b2006 EB
082	0	4	_a611.01816
082	0	4	_a599.935
100	1		_aSilverman, Scott K _984253 _0Local
245	1	0	_aNucleic Acid Switches and Sensors _cby Scott K. Silverman
260			_aBoston, MA _bSpringer International Publishing _c2006
300			_a1 recurso en línea (IX, 125 p.)
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
338			_aonline resource _bcr _2rdacarrier
520			_aIn this book, seven chapters describe studies aimed at understanding and exploiting the key features of such molecular RNA and DNA devices. In the first section of the book, four chapters are devoted to artificial nucleic acid switches and sensors. These chapters introduce the concept of allosteric ribozymes as molecular switches and sensors; describe nucleic acid enzymes that are switched by oligonucleotides and other nucleic acid enzymes that are switched by proteins; and illustrate how switching elements can be integrated ration-ally into fluorescently signaling molecular sensors made out of nucleic acids. In the second section of the book, three chapters show that nature has been as crafty a molecular-scale engineer as any modern scientist via evolution of natural nucleic acid switches and sensors. RNAs have been found whose activities are modulated either by proteins or by small-molecule metabolites, and both kinds of system are described. Finally, the notion of exploiting naturally occurring RNA switches for drug development is discussed.
650	0	7	_aARN _9144940 _2embne
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-0-387-47257-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9780387472577
907			_a.b12813278 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQP623.5.C36 S558 2006 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11542652 _z06-04-17
988			_aEBOOK, EBSPRINGERrevisado
998			_am _a_alco _a_vill _b03-01-17 _cm _dz _ef _feng _gxxu _h0