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020			_a9780387399263
040			_aES-MaUEC
050		4	_aRC600 _b.O374 2006 EB
082	0	4	_a616.079
100	1		_aOksenberg, Jorge _984240 _0Local
245	1	0	_aImmunogenetics of autoimmune Disease _cby Jorge Oksenberg, David Brassat
260			_aBoston, MA _bSpringer International Publishing _c2006
300			_a1 recurso en línea (XIII, 158 p.)
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
338			_aonline resource _bcr _2rdacarrier
490	1		_aMedical Intelligence Unit
520			_autoimmunity is the downstream outcome of a rather extensive and coordinated series of events that include loss of self-tolerance, peripheral lymphocyte Aactivation, disruption of the blood-systems barriers, cellular infiltration into the target organs and local inflammation. Cytokines, adhesion molecules, growth factors, antibodies, and other molecules induce and regulate critical cell functions that perpetuate inflammation, leading to tissue injury and clinical phenotype. The nature and intensity of this response as well as the physiological ability to restore homeostasis are to a large extent conditioned by the unique amino acid sequences that define allelic variants on each of the numerous participating mol{u00AD} ecules. Therefore, the coding genes in their germline configuration play a primary role in determining who is at risk for developing such disorders, how the disease progresses, and how someone responds to therapy. Although genetic components in these diseases are clearly present, the lack of obvious and homogeneous modes of transmission has slowed progress by prevent{u00AD} ing the full exploitation of classical genetic epidemiologic techniques. Furthermore, autoimmune diseases are characterized by modest disease risk heritability and m- tifaceted interactions with environmental influences. Yet, several recent discoveries have dramatically changed our ability to examine genetic variation as it relates to human disease. In addition to the development of large-scale laboratory methods and tools to efficiently recognize and catalog DNA diversity, over the past few years there has been real progress in the application of new analytical and data-manage{u00AD} ment approaches.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aEnfermedades autoinmunes _0comprobar BNE19901038259 _2embne _9143353
700	1		_aBrassat, David _984241 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-0-387-39926-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9780387399263
907			_a.b12813217 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b22-06-17 _cm _dz _ef _feng _gxxu _h0
945			_aRC600 .O374 2006 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11542597 _z06-04-17
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