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008			100301s2006 xxu| s |||| 0|eng d
020			_a9780387366739
040			_aES-MaUEC
050		4	_aQH603.C4 _bG669 2006 EB
100	1		_aGonzalez-Mariscal, Lorenza _984232 _0Local
245	1	0	_aTight Junctions _cby Lorenza Gonzalez-Mariscal
260			_aBoston, MA _bSpringer International Publishing _c2006
300			_a1 recurso en línea (XI, 224 p.)
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
338			_aonline resource _bcr _2rdacarrier
520			_aight junctions (TJs) are cell-ceil adhesion belts that encircle epithelial and endothelial cells at the limit between the apical and the lateral Tmembrane. These junctions are crucial for the establishment of separate compartments in multicellular organisms and for the exchange of substances between the internal milieu and the external environment. The perception of TJs has changed over the years. From being regarded as static paracellular seals, they have come to be perceived as dynamic structures that adjust their morpholÂ{u0BE7}y and function in response to physiological, pharmacological and pathologiÂ{u08E1}l challenges. The roles that TJs play in epithelial and endothelial cells has also widened, and nowadays this structure is regarded not only as a fence that limits within the membrane, the movement of proteins and lipids between the apical and basolateral membranes, or as a gate that regulates in a size and charge selecÂ{u0D29}ve manner the transit of ion and molecules through the paracellular pathway, but also as a structure integrated by molecules that participate in the control of cell proliferation. These observations highlight the importance of understandÂ{u0A6E}g TJ physiology in order to develop effective strategies for the treatment of pathological conditions such as cancer and autoimmune diseases. This broader perception of TJs is reflected in all the chapters of the book and has been attained thanks to the identification in recent years of a wide array of proteins that constitute TJs in epithelial and endothelial cells as well as in central nervous system myelin.
650	0	7	_aCitología _9139477 _2embne
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/0-387-36673-3 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9780387366739
907			_a.b12813138 _b10-10-17 _c01-10-14
942			_2lcc _cLE
945			_aQH603.C4 G669 2006 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11542512 _z06-04-17
988			_aEBOOK, EBSPRINGERrevisado
998			_am _a_alco _a_vill _b03-01-17 _cm _dz _ef _feng _gxxu _h0