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001			75692
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007			cr nn 008mamaa
008			100301s2006 xxu| s |||| 0|eng d
020			_a9780387360638
040			_aES-MaUEC
050		4	_aQP551 _b.M877 2006 EB
100	1		_aMurphy, Regina M _984227 _0Local
245	1	0	_aMisbehaving Proteins : _bProtein (Mis)Folding, Aggregation, and Stability _cby Regina M Murphy, Amos M Tsai
260			_aNew York, NY _bSpringer International Publishing _c2006
300			_a1 recurso en línea (VIII, 353 p.)
336			_aTexto (visual) _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
338			_aonline resource _bcr _2rdacarrier
520			_aMisfoldedaggregatedproteinoncewasconsideredasinterestingasyesterdayâ€{u3D32}ashâ€{u1822}othersome by-product of important and productive activities, to be disposed of and forgotten as quickly as possible. Yesterdayâ€{u3834}rash has become todayâ€{u3826}ocus of cons- erable scienti?c interest for at least two reasons: (1) protein aggregates are at the core of a number of chronic degenerative diseases such as Alzheimerâ€{u3824}isease, and (2) - gregation poses signi?cant obstacles to the manufacture of safe, ef?cacious, and stable protein products. As interest in protein misfolding, aggregation, and stability has soared beyond the core group of traditional protein-folding scientists, and as substantial scienti?c progress in understanding and controlling protein misfolding has been achieved, the need to summarize the state of the art became manifest. Although there are many excellent texts and edited collections on protein structure and folding, these volumes tend to relegate protein misfolding and aggregation to a minor role. Review articles and books focused on the biological role of protein aggregates in diseases have been published recently. Misbehaving Proteins: Protein (Mis)folding, Aggregation, and Stability differs from theseotherrecenteffortsinitsemphasisonfundamentalcomputationalandexperimental studies and in its linkage of disparate consequences of protein misfolding (e.g., from clinical manifestations to manufacturing headaches) to their common causes.
942			_2lcc _cLE
988			_aEBOOK, EBSPRINGERrevisado
650		7	_aProteínas _0comprobar BNE19900977845 _2embne _9139861
700	1		_aTsai, Amos M _984228 _0Local
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://link.springer.com/book/10.1007/978-0-387-36063-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
901			_ai9780387360638
907			_a.b12813102 _b10-10-17 _c01-10-14
998			_am _a_alco _a_vill _b03-01-17 _cm _dz _ef _feng _gxxu _h0
945			_aQP551 .M877 2006 EB _g1 _ieBOOK _j0 _lmae _o- _pEUR0.00 _q- _r- _sb _t15 _u0 _v0 _w0 _x0 _y.i11542482 _z06-04-17
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