000			03747nam a22002895i 4500
001			402995
003			ES-MaUEC
005			20240528105949.0
007			cr nn 008mamaa
008			240219s2023 sz | o |||| 0|eng d
020			_a9783031419430
024	7		_a10.1007/978-3-031-41943-0 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQH588.S83 _b2023 EB
245	0	0	_aPluripotent Stem Cell Therapy for Diabetes _cedited by Lorenzo Piemonti, Jon Odorico, Timothy J Kieffer, Valeria Sordi, Eelco de Koning
250			_a1st ed. 2023
264		1	_aCham _bSpringer International Publishing _c2023
300			_a1 recurso en línea
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aMimicking pancreas development with human pluripotent stem cells -- Pancreatic cell fate specification: insights into developmental mechanisms and their application for lineage reprogramming -- The evolution of methods for in vitro differentiation of stem cell derived islets -- Signaling pathways that govern the formation, expansion and maturation of pancreatic progenitors -- Building islets from the ground up using stem cells -- Pancreatic progenitor proliferation -- Selecting biocompatible biomaterials for stem cell derived islet transplantation -- Scaffolds for encapsulation of stem-cell-derived {esc}(Sb{esc}(B cells -- 3d printing of new islets -- Biological scaffolds and hydrogels in islet organoids -- 3-D organoids of mesenchymal stromal and pancreatic islet cells -- Bioengineered insulin producing endocrine tissues -- Bioactive materials for cell encapsulation -- Strategies to boost islet graft oxygenation -- Vascularizing device strategies -- Immunogenicity of stem cell derived islets -- Immune evasive stemcell islets -- Encapsulation of stem cell-derived islets: recent progress -- Islet immunoengineering -- Stem cell genome editing tools -- Selection of SC-derived pancreatic progenitors and {esc}(Sb{esc}(B cell -- Considerations pertaining to implant sites for cell-based insulin replacement -- Safety switches in pluripotent stem cells -- Safety: teratoma risk -- Stem cell derived islets transplantation in non-human primates -- Social / Legal / Ethical issues pertaining to use of pluripotent stem cells -- Cost-effectiveness considerations for stem cell derived islet replacement therapy -- Lessons from clinical trials of islet cell replacement -- Scale up and Biomanufacturing of Stem Cell- derived Islets -- Minimal SC-{esc}(Sb{esc}(B cell properties for transplantation in diabetic patients -- Autologous stem cell islets for patients with chronic pancreatitis and diabetes -- Clinical Trials -- Modeling monogenic diabetes with stem cells -- Stem and progenitor cells in pancreas development, regeneration and drug screening. .
520			_aThis is a unique book containing comprehensive coverage of pluripotent stem cell therapies for the treatment of diabetes. The greatest enthusiasm for treatment lies in the possibility of using stem cells to overcome the limits of islet transplantation. Organized into six parts, this book covers the development and differentiation of beta cells, bioengineering, immunoescape, preclinical model and translational approaches, beta cell replacement, and disease modeling. This is an ideal book for scientists, researchers, and clinicians working in the area of stem cell technology in the treatment of diabetes.
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-41943-0 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
988			_aSpringer_Medicine_2023
999			_c402995 _d402995