000			03454nam a22003015i 4500
001			402978
003			ES-MaUEC
005			20240528105947.0
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008			240212s2023 sz | o |||| 0|eng d
020			_a9783031343049
024	7		_a10.1007/978-3-031-34304-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQH573-671 _b2023 EB
100	1		_aShapiro, Irving M. _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut
245	0	0	_aMechanisms of Mineralization of Vertebrate Skeletal and Dental Tissues _cby Irving M Shapiro, William J Landis
250			_a1st ed. 2023
264		1	_aCham _bSpringer International Publishing _c2023
300			_a1 recurso en línea
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aIntroduction -- In the Beginning -- The Enigma of Edith: Free Energy, Nucleation and the Formation of Mineral -- Form and Function of Tissues that Undergo Mineralization -- Genes and Gene Networks Regulating Mineralization -- Calcium and Phosphate Ion Uptake, Distribution and Homeostasis in Cells of Vertebrate Mineralizing Tissues -- Calcium and Phosphate Ion Efflux from Cells: The Roles of Matrix Vesicles, Extracellular Vesicles, and Other Membrane-invested Transporters in Vertebrate Hard Tissue Mineralization -- Collagen-based Mineralization of Bones, Teeth and Other Vertebrate Skeletal Tissues -- The Role of Non-collagenous Proteins and Other Matrix Molecules in Vertebrate Mineralization -- Local and Systemic Regulation of Mineralization: Role of Coupling Factors, Pyrophosphate, Polyphosphates, Vitamin D, Fetuin, Matrix Gla Protein and Osteopontin -- Observations Concerning Mineral Deposition in Soft Tissues: Regulation of Aberrant Mineral Deposits -- Epilogue.
520			_aThe book presents a multi-disciplinary approach to understanding mechanisms regulating the formation of mineral in vertebrate skeletal and dental tissues. The focus of the book is directed toward the mineralization process, an evolutionarily conserved system in which cells synthesize a complex and unique extracellular matrix into which mineral is deposited. Regulatory control is viewed though lenses that emphasize the genetic, physical-chemical, biochemical, structural, cellular and extracellular aspects of the mineralization process as they relate to crystal nucleation, growth and maturation. Throughout the book, defects in regulation at the genetic and transcriptional levels are linked to the numerous clinical problems associated with the mineralization of bone, cartilage, tendon, tooth, and soft tissues. The book serves as a comprehensive text for basic scientists and scholars working in the many areas that comprise hard tissue research, as well as undergraduate and graduatestudents, postdoctoral fellows and those contemplating working in the field of biomineralization or who need a review of a specific mineralization topic. The information contained in the book is relevant for clinicians and clinical scientists in the fields of orthopaedic surgery, veterinary medicine, dentistry, endocrinology, aging and genetics.
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-34304-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
988			_aSpringer_Medicine_2023
999			_c402978 _d402978