000			02733nam a22003015i 4500
001			402949
003			ES-MaUEC
005			20240528105945.0
007			cr nn 008mamaa
008			240124s2023 sz | o |||| 0|eng d
020			_a9783031481055
024	7		_a10.1007/978-3-031-48105-5 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRC321-580 _b2023 EB
100	1		_aWalz, Wolfgang. _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut
245	0	0	_aThe Gliocentric Brain : _bPhenotype Plasticity of the Damaged Brain _cby Wolfgang Walz
250			_a1st ed. 2023
264		1	_aCham _bSpringer International Publishing _c2023
300			_a1 recurso en línea
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_a1. Introduction -- 2. The Brain as an Organ -- 3. Life Cycle -- 4. Reactive Microglia and Astrocyte Phenotype Transitions. 5. Transition of Microglia to Reactive States -- 6. Reactive Astrocytes -- 7. Neuroinflammation -- 8. The Brain and the Immune System -- 9. Viral and Bacterial Infections -- 10. Autoimmune Reactions -- 11. Adult Glial Cell Proliferation and Neurogenesis -- 12. Glioma -- 13. Neurodegenerative Disorders -- 14. Vascular Diseases -- 15. Seizures -- 16. Traumatic Brain Injury -- 17. Major Psychiatric Disorders -- 18. Glia in Recovery Processes and Repair -- 19. Glial Phenotype Plasticity.
520			_aThe brain is the body's most vulnerable organ due to the defined roles of neurons within circuits. Neurons are vastly outnumbered by microglia, astrocytes, oligodendrocytes, macrophages, cells of the blood brain barrier and invading immune cells. These cells display different grades of reactivities and interactions. They integrate their responses and not only change phenotypes but can also completely reprogram after damage to protect the neuronal complexity. The interactions of these satellite cells in the healthy brain are described as well as their roles in all major brain diseases. Special emphasis is put on immune system - brain interactions and regenerative and repair processes. The gliotic response is compared with the reactions to injuries of the skin and other organs. A final chapter addresses the definition of a cell type. It concludes that cell types can no longer be regarded as defined entities over the body's lifetime but are prone to phenotype plasticity and even complete reprograming.
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-48105-5 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
988			_aSpringer_Medicine_2023
999			_c402949 _d402949