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008			230609s2023 sz | fo |||| 0|eng d
020			_a9783031069208
024	7		_a10.1007/978-3-031-06920-8 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRD123 _b2023 EB
100	1		_aRosenberg, Nahum _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9690662
245	1	0	_aBiophysical Osteoblast Stimulation for Bone Grafting and Regeneration : _bFrom Basic Science to Clinical Applications _cby Nahum Rosenberg
250			_a1st ed. 2023
264		1	_aCham _bSpringer International Publishing _c2023
300			_a1 recurso en línea
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_a1 Theoretical framework supporting the research of biophysical stimulation of osteoblasts -- 2. Methodologies used and their rationale -- 3. Osteoblast explant cultures -- 4. End parameters -- 5. Determination of in vitro generated tissue -- 6. In vitro safety studies -- 7. In vivo safety evaluation -- 8. Efficacy in vivo studies -- 9. Setups for external application of biophysical energy -- 10. Mechanical stimulation -- 11. The original contribution to knowledge -- 12. Contribution to developing the theory in the field -- 13. The impact of the work on professional practice -- 14. The nature of the work's academic impact -- 15. The strengths and weaknesses of the methodologies used (critical analysis) -- 16. Conclusion.
520			_aThis book integrates the current basic and clinical knowledge in the area of biophysical stimulation of osteoblast for in vitro and in vivo live bone generation. This innovative methodology and its applications are presented and discussed in several clinical conditions: treatment of fracture nonunion, spine stabilization, bone replacement after tumor resections, stabilization of failed joint endoprostheses in revision surgery and in treatment of bone loss (osteoporosis and osteopenia). The author analyses different types of biophysical stimulation of osteoblasts for bone regeneration, e.g. mechanical (static and alternating, including distraction osteogenesis), electromagnetic (pulsed, alternating, static), light (at different spectrum range, including laser), acoustic (including ultrasound), RF etc. Moreover, he summarizes and discusses the most significant findings for in vitro bone generation and its resulting clinical use as autologous bone graft without surgical morbidity. Reflecting the author's extensive experience this book is an excellent source of knowledge and a valuable aid to clinical practice for all orthopedic surgeons, fellows, and researchers wanting to gain insights into this promising field. .
988			_aSpringer_Medicine_2023
650		7	_2embne _9313163 _aHuesos _xRegeneración
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-06920-8 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b08/2024 _dz _eb _zSI