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020 _a9783031245756
024 7 _a10.1007/978-3-031-24575-6
_2doi
040 _aES-MaUEC
_bspa
_cES-MaUEC
_dES-MaUEC
050 4 _aQP552 .L5
_b2023 EB
245 0 0 _aLipoprotein(a)
_cedited by Karam Kostner, Gerhard M. Kostner, Peter P. Toth
250 _a1st ed. 2023
264 1 _aCham
_bSpringer International Publishing
_c2023
300 _a1 recurso en línea
336 _atexto
_btxt
_2rdacontent
337 _aelectrónico
_bc
_2rdamedia
338 _arecurso electrónico
_bcr
_2rdacarrier
490 0 _aContemporary Cardiology
_x2196-8977
505 0 _a60 years of Lp(a) research-From Ouchterlonys double diffusion to a significant risk factor for CHD -- Lp(a) structure and composition -- Genetics of Lipoprotein(a) -- Lp(a) metabolism -- Contemporary aspects of Lp(a) metabolism and therapies based on tracer kinetic methods -- Role of Proprotein Convertase Subtilisin Kexin type 9 in Lipoprotein(a) Metabolism -- The Role of Cell Surface Receptors in Lp(a) Metabolism -- Physiological Roles And Functions Of Lipoprotein(a) -- The role of Lp(a) in Atherosclerosis: An overview -- Role of macrophages in Lp(a) pathophysiology -- Thrombosis, Inflammation and Lipoprotein(a): Clinical Implications -- The role of the kidney in Lp(a) physiology and pathophysiology -- Lp(a) as a cardiovascular risk factor -- Lp(a) and aortic valve stenosis, stroke, and other non-coronary cardiovascular diseases -- Lp(a) in cardiovascular disease: Evidence from Large Epidemiological Studies -- Lipoprotein(A) And Immunity -- When to measure Lp(a) -- Measurement of Lipoprotein (a) in the Clinical Laboratory -- Standardization of analytical methods for the measurement of Lipoprotein(a): bridging past and future initiatives -- Establishing an SI-traceable Reference Measurement System for Lp(a), based on Quantitative Protein Mass Spectrometry and Molar Units -- Compounds that impact Lp(a) concentrations -- Antisense oligonucleotide therapy to treat elevated lipoprotein(a) -- Lipoprotein apheresis for reduction of Lipoprotein(a) -- Elevated Lp(a) - Why Should I Test For It, If I Cannot Treat It? A Patient's Perspective -- Burning unanswered questions Therapy.
520 _aLipoprotein(a) [Lp(a)] is a unique lipoprotein that has emerged as an independent risk factor for cardiovascular vascular disease. Data from case control, epigenetic and mendelian randomization studies indicate that people with elevated Lp(a) have a two-fold to four-fold increased risk of cardiovascular events compared to people with low Lp(a) levels. Despite this risk, awareness of Lp(a) is still very low among health care providers. Even cardiologists often overlook Lp(a), in part because Lp(a) is not as well-understood as other risk factors and treatment options are still very limited. This book offers an authoritative and comprehensive overview of Lipoprotein(a). It provides an in-depth review of all aspects of Lp(a), from pathophysiology to metabolism. Chapters offer the reader a contemporary view of the important roles of Lp(a) as a risk factor for cardiovascular disease. In addition, this volume discusses the clinical implications of elevated Lp(a) and current and future therapies. Lipoprotein(a) is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in lipidology, cardiology, endocrinology, pharmacotherapy, and health promotion and disease prevention.
988 _aSpringer_Medicine_2023
650 7 _2embne
_9146390
_aLipoproteínas
856 4 0 _uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-24575-6
_zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942 _2lcc
_cLE
998 _b06/2024
_dz
_eb
_zSI