000			03609nam a2200337 i 4500
999			_c399365 _d399365
001			399365
003			ES-MaUEC
005			20240415172841.0
006			a||||fo|||| 00| 0
007			cr nn 008mamaa
008			231018s2023 sz | fo |||| 0|eng d
020			_a9783031387319
024	7		_a10.1007/978-3-031-38731-9 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP552 .P4 _b2023 EB
100	1		_aLangel, Ülo _eautor _4aut _4http://id.loc.gov/vocabulary/relators/aut _9670454
245	1	0	_aCPP, Cell-Penetrating Peptides _cby Ülo Langel
250			_a2nd ed. 2023
264		1	_aCham _bSpringer International Publishing _c2023
300			_a1 recurso en línea
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_a1. Introduction -- 2. Classes and applications of CPP -- 3. CPP selection, prediction and in silico analysis -- 4. Labeling of CPPs -- 5. Methods for CPP functionalization with oligonucleotides -- 6. Additional (gene therapeutic) platforms -- 7. Protein delivery and mimicry -- 8. General targeting strategies -- 9. Targeting specific barriers -- 10. Methods for molecular imaging, detection and visualization of CPPs -- 11. Methods for structural studies of CPPs -- 12. Kinetics -- 13. Toxicity and immune response -- 14. Cell-translocation mechanisms of CPPs -- 15. Clinical trials and commercialization using CPPs -- 16. Therapeutic potential of CPPs -- 17. CPP functionalized nanoparticles -- 18. Concluding remarks.
520			_aIn this book, a summary and update of the most important areas of cell-penetrating peptides (CPP) research are presented, while raising relevant questions for further development. The CPP sequences are presented and discussed throughout the book. The methods for testing CPP mechanisms are discussed in detail. Various approaches for the testing of endocytotic pathways of CPP uptake are also described. Different CPP uptake experiments are compared since it is becoming clear that it is often best to apply several methods in a complementary manner in order to most comprehensively evaluate CPP uptake mechanisms due to the complexity of these processes. A brief summary of functionality issues of CPPs, both in vitro and in vivo, is discussed. Therapeutic potential of CPPs and commercial developments are discussed. The present, second edition of this book is the updated and expanded version of the first edition, published in 2019. The development of the field of cell-penetrating peptides in these five years has been obvious and exciting. This second edition of the book has been partly reorganized and comprehensively expanded with the exciting research in 2019-2023. Around 2500 novel scientific articles have become available, most of them are reviewed in the second edition. Additional rapidly growing areas of high impact presented in this second edition are therapeutic developments (Chapter 16) and delivery of oligonucleotides and proteins/peptides (Chapters 5 and 6) including novel reports on genome editing with CPP assistance. Also, several additional examples are available now on clinical trials using CPPs (Chapter 15). The book is written for researchers and students in the field.
988			_aSpringer_BiomedLife_2023
650		7	_2embne _9146243 _aPéptidos
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-38731-9 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b04/2024 _dz _eb _zSI