000			02902nam a2200337 i 4500
999			_c399352 _d399352
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003			ES-MaUEC
005			20240415155850.0
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007			cr nn 008mamaa
008			230426s2023 sz | fo |||| 0|eng d
020			_a9783031315237
024	7		_a10.1007/978-3-031-31523-7 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQH603 .I54 _b2023 EB
245	0	0	_aEndolysosomal Voltage-Dependent Cation Channels _cedited by Christian Wahl-Schott, Martin Biel
250			_a1st ed. 2023
264		1	_aCham _bSpringer International Publishing _c2023
300			_a1 recurso en línea
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aHandbook of Experimental Pharmacology _x1865-0325 _v278
505	0		_aPart I: Physiological Functions of Endo-lysosomal Cation Channels -- NAADP-Mediated Ca2+ Signalling -- NAADP-Dependent TPC Current -- NAADP-Evoked Ca2+ Signaling: The DUOX2-HN1L/JPT2-Ryanodine Receptor 1 Axis -- TPC Functions in the Immune System -- Lysosomal Ion Channels and Lysosome- 1 Organelle Interactions -- TRPML1 and TFEB, an Intimate Affair -- Lysosomal Potassium Channels -- Part II Structure and Composition of TPC and TRPML Channels -- Structure and Function of Plant and Mammalian TPC Channels -- A Structural Overview of TRPML1 and the TRPML Family -- Endo-Lysosomal Two-Pore Channels and Their Protein Partners -- Part III: Tools and Methods to Characterize Endolysosomal Cation Channels -- Electrophysiological Techniques on the Study of Endolysosomal Ion Channels -- The Plant Vacuole as Heterologous System to Characterize the Functional Properties of TPC Channels -- Expanding the Toolbox: Novel Modulators of Endolysosomal Cation Channels -- Characterization of Endo-Lysosomal Cation Channels Using Calcium Imaging.
520			_aThis book covers the molecular structures and the cellular and in vivo function of endosomes and lysosomes, i.e. intracellular vesicles which are involved in many cellular processes such as endocytosis, intracellular trafficking, degradation of material from inside (e.g. autophagy) and outside the cell as well as exocytosis. Membranes of endolysosomal organelles contain an amazing number and diversity of ion channels. These ion channels are the topic of the present book that focusses on describing the structure, the biophysical properties, physiological functions of endolysosomal ion channels at the molecular, cellular and in vivo level. .
988			_aSpringer_BiomedLife_2023
650		7	_2embne _9155847 _aCanales iónicos
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-31523-7 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b04/2024 _dz _eb _zSI