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003			ES-MaUEC
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007			cr nn 008mamaa
008			221108s2023 sz | o |||| 0|eng d
020			_a9783031173622
024	7		_a10.1007/978-3-031-17362-2 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQH588 .S83 _b2023 EB
245	0	0	_aAutophagy in Stem Cell Maintenance and Differentiation _cedited by Bhupendra V Shravage, Kursad Turksen
250			_a1st ed. 2023
264		1	_aCham _bSpringer International Publishing _c2023
300			_a1 recurso en línea
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
490	0		_aStem Cell Biology and Regenerative Medicine _x2196-8993 _v73
505	0		_aAssays for monitoring autophagy in stem cells -- Autophagy in Stem Cell Maintenance and Differentiation -- Autophagy in Embryonic stem cells and Neural stem cells -- Autophagy in Germline Stem Cells -- The role of autophagy in the regulation of hematopoietic stem cells -- Autophagy in Muscle Stem Cells -- Autophagy in Intestinal Stem Cells -- The autophagy lysosomal pathway: friend or foe in adult neural stem cells? -- Autophagy in Mesenchymal Stem Cell-based therapy -- Autophagic control of stem cells differentiation into osteogenic lineage- Implications in bone disorders -- Autophagy in Cancer Metastasis.
520			_aThis book covers a wide range of topics that illustrate the various functions of autophagy in stem cells and offers insights on the mechanisms by which autophagy can regulate stem-cell self-renewal and facilitate specific differentiation programs. Stem cells are unique cells present in most multicellular animals and are essential for their survival. They have two unique properties: the ability to self-renew and the ability to differentiate into one or more cell types. These characteristics of stem cells have found immense therapeutic potential in regenerative medicine. Autophagy is a crucial membrane trafficking pathway that is essential for maintaining cellular homeostasis that involves sequestration of non-functional proteins, protein aggregates and damaged organelles in double-membraned vesicles called autophagosomes, which are subsequently targeted to the lysosome for degradation. The primary aim of this book is to provide knowledge of recent developments in our understanding of the role of autophagy in stem cells, including germline stem cells. Autophagy is considered a promising target for many diseases. Significant efforts are being developed to identify specific modulators of autophagy, which will aid in designing combinatorial therapeutic strategies that will allow significant improvements in regenerative medicine.
988			_aSpringer_BiomedLife_2023
650		7	_2embne _9160528 _aCélulas madre
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-17362-2 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b05/2024 _dz _eIG _zSI