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008			230428s2023 si | o |||| 0|eng d
020			_a9789811985201
024	7		_a10.1007/978-981-19-8520-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aRM666 .N87 _b2023 EB
245	0	0	_aNucleic Acid Biology and its Application in Human Diseases _cedited by Subhrangsu Chatterjee, Samit Chattopadhyay
250			_a1st ed. 2023
264		1	_aSingapore _bSpringer Nature Singapore _c2023
300			_a1 recurso en línea
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aChapter 1_Nucleic Acid Structure and biology -- Chapter 2_Nucleic acid-mediated inflammatory diseases -- Chapter 3_ Alternative splicing and cancer -- Chapter 4_Nucleic acid-based strategies to treat neurodegenerative movement -- Chapter 5_Human Diseases induced by Oxidative damage in DNA -- Chapter 6_Nucleic Acid in Nanotechnology -- Chapter 7_ Nucleic Acid in Diagnostics -- Chapter 8_Nucleic Acid as sensors and logic gates -- Chapter 9_ Nucleic Acid Therapeutics in Cancer Biology -- Chapter 10_ Nucleic Acid as Vaccine -- Chapter 11_Nucleic Acid Editing to combat diseases.
520			_aThis book reviews the structure-function relationship of nucleic acids, their role in the pathophysiology of the diseases, and as therapeutic targets for human diseases. The chapters discuss the role of nucleic acids in inflammatory diseases, neurodegenerative diseases, and cancer. The book also describes recent advancements in nucleic acid-based therapy, the application of nucleic acids in diagnostics, in the development of nano-carriers, logic gates, and sensors. It explores the use of nucleic acids (RNA and DNA) as a unique and multifunctional platform for numerous applications, including therapeutics, diagnostics, nanodevices, and materials. It further examines the role of DNA methylation, histone modifiers and readers, chromatin remodelers, microRNAs, and other components of chromatin in the progression of cancer. The book also discusses the applications of nucleic acid as a vaccine and as a gene-editing tool. It also provides an overview of the clinical trials using genome editing platforms for disease treatment and the challenges in implementing the editing technology. Finally, the book elucidates a representative description of challenges associated with nucleic acid-mediated therapy.
988			_aSpringer_BiomedLife_2023
650		7	_2embne _9140525 _aÁcidos nucleicos _xUso terapéutico
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-981-19-8520-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b05/2024 _dz _eIG _zSI