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008			230610s2023 sz | o |||| 0|eng d
020			_a9783031322761
024	7		_a10.1007/978-3-031-32276-1 _2doi
040			_aES-MaUEC _bspa _cES-MaUEC _dES-MaUEC
050		4	_aQP86 _b2023 EB
100	1		_aNydegger, U. E. _eautor _9689909
245	1	0	_aSenescence Back and Forth _cby Urs Nydegger, Thomas Lung
250			_a1st ed. 2023.
264		1	_aCham _bSpringer International Publishing _c2023
300			_a1 recurso en línea
336			_atexto _btxt _2rdacontent
337			_aelectrónico _bc _2rdamedia
338			_arecurso electrónico _bcr _2rdacarrier
505	0		_aSenescence opposed to longevity -- Genetics, the language of Proteomics -- Plants Uncover Senescence Animals Way Off Humans -- Rejuvenation stops Senescence -- Overlap of Senescence with Disease -- Mosaic Restricted to the Individuum -- Remaining Time until Death -- Laboratory Checkups -- eroprotectors.
520			_aThis book is about lifelong ageing of humans. The basic biochemical and genetic mechanisms remain ill known, and differ among individuals. The book starts out to explore the plant and animal kingdoms to answer questions human ageing needs for understanding. First, we come to scrutinize time running out and what 'normal' means with impacts on the genome and on protein half- lives and function. Ageing goes beyond biochemical skid treated by geroprotector drugs, including biosimilars; albeit early diagnosis with standard medical laboratory assays, here addressed, sheds light with focus on basic research. Modern tools, including machine learning, and DNA technology, e.g. genomics, have already provided for unanticipated insights. The chapters then turn around senescence of the entire organism based on variable ageing of single organs embedded in neuronal networks . Psychological stress factors, dementia opposed to vigilance, and distinction of ageing from overt disease are contrasting in humans and are opposed in the book. Senescence, seen as a one way track may be reverted into rejuvenation, made possible by insights into immunosenescence and genomic approaches. Risk management in health insurance finds important clues in this book. The topics addressed between the book covers help to understand the trend to the ever- prolonging life expectancy beyond the centenarian age group; nursing care takers and pharmaceutical industry are invited to understand what' is going on in senior people to make their geriatric population remain fit or become frail.
988			_aSpringer_BiomedLife_2023
650		7	_2embne _9141231 _aEnvejecimiento
856	4	0	_uhttps://go.openathens.net/redirector/universidadeuropea.es?url=https://doi.org/10.1007/978-3-031-32276-1 _zAcceso a este recurso digital (usuarios Universidad Europea de Madrid)
942			_2lcc _cLE
998			_b04/2024 _dz _ek _zSI